Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization

RBM20 is a major regulator of heart-specific alternative pre-mRNA splicing of TTN encoding a giant sarcomeric protein titin. Mutation in RBM20 is linked to autosomal-dominant familial dilated cardiomyopathy (DCM), yet most of the RBM20 missense mutations in familial and sporadic cases were mapped to...

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Detalles Bibliográficos
Autores principales: Murayama, Rie, Kimura-Asami, Mariko, Togo-Ohno, Marina, Yamasaki-Kato, Yumiko, Naruse, Taeko K., Yamamoto, Takeshi, Hayashi, Takeharu, Ai, Tomohiko, Spoonamore, Katherine G., Kovacs, Richard J., Vatta, Matteo, Iizuka, Mai, Saito, Masumi, Wani, Shotaro, Hiraoka, Yuichi, Kimura, Akinori, Kuroyanagi, Hidehito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997748/
https://www.ncbi.nlm.nih.gov/pubmed/29895960
http://dx.doi.org/10.1038/s41598-018-26624-w

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