Cargando…

Repositioning of Omarigliptin as a once-weekly intranasal Anti-parkinsonian Agent

Drug repositioning is a revolution breakthrough of drug discovery that presents outstanding privilege with already safer agents by scanning the existing candidates as therapeutic switching or repurposing for marketed drugs. Sitagliptin, vildagliptin, saxagliptin & linagliptin showed antioxidant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ayoub, Bassam M., Mowaka, Shereen, Safar, Marwa M., Ashoush, Nermeen, Arafa, Mona G., Michel, Haidy E., Tadros, Mariam M., Elmazar, Mohamed M., Mousa, Shaker A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997767/ https://www.ncbi.nlm.nih.gov/pubmed/29895906 http://dx.doi.org/10.1038/s41598-018-27395-0

Ejemplares similares

Enhanced Extraction Technique of Omarigliptin from Human Plasma—Applied to Biological Samples from Healthy Human Volunteers
por: Mowaka, Shereen, et al.
Publicado: (2020)

Pharmacokinetic Evaluation of Empagliflozin in Healthy Egyptian Volunteers Using LC-MS/MS and Comparison with Other Ethnic Populations
por: Ayoub, Bassam M., et al.
Publicado: (2017)

Investigation of Pharmacokinetic Parameters of Trelagliptin in Egyptian Volunteers Using Sensitive LC-MS/MS: A Comparative Study with a Japanese Population
por: Mowaka, Shereen, et al.
Publicado: (2021)

Repurposing of Omarigliptin as a Neuroprotective Agent Based on Docking with A(2A) Adenosine and AChE Receptors, Brain GLP-1 Response and Its Brain/Plasma Concentration Ratio after 28 Days Multiple Doses in Rats Using LC-MS/MS
por: Ayoub, Bassam M., et al.
Publicado: (2021)

Repositioning of dipeptidyl peptidase-4 inhibitors and glucagon like peptide-1 agonists as potential neuroprotective agents
por: Mousa, Shaker A., et al.
Publicado: (2019)

Efficacy of omarigliptin, once-weekly dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes
por: Kawasaki, Eiji, et al.
Publicado: (2021)

Suitability of various chromatographic and spectroscopic techniques for analysis and kinetic degradation study of trelagliptin
por: Zaghary, Wafaa A., et al.
Publicado: (2017)

Different Spectrophotometric Methods for Simultaneous Determination of Trelagliptin and Its Acid Degradation Product
por: Mowaka, Shereen, et al.
Publicado: (2018)

The effects of Omarigliptin on promoting osteoblastic differentiation
por: Liao, Fake, et al.
Publicado: (2021)

Economic Spectrofluorometric Bioanalysis of Empagliflozin in Rats' Plasma
por: Ayoub, Bassam, et al.
Publicado: (2021)

Single and multiple dose pharmacokinetics and pharmacodynamics of omarigliptin, a novel, once‐weekly dipeptidyl peptidase‐4 inhibitor, in healthy Japanese men
por: Tsuchiya, Saori, et al.
Publicado: (2016)

Pharmacokinetics and Pharmacodynamics of Omarigliptin, a Once‐Weekly Dipeptidyl Peptidase‐4 (DPP‐4) Inhibitor, After Single and Multiple Doses in Healthy Subjects
por: Krishna, Rajesh, et al.
Publicado: (2016)

The efficacy and safety of once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus: A systemic review and meta-analysis
por: Wang, Xianying, et al.
Publicado: (2018)

A randomized, placebo-controlled study of the cardiovascular safety of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus
por: Gantz, Ira, et al.
Publicado: (2017)

Omarigliptin alleviates cognitive dysfunction in Streptozotocin-induced diabetic mouse
por: Li, Xiaoyan, et al.
Publicado: (2022)

Omarigliptin inhibits brain cell ferroptosis after intracerebral hemorrhage
por: Zhang, Yan, et al.
Publicado: (2023)

A randomised, double‐blind, trial of the safety and efficacy of omarigliptin (a once‐weekly DPP‐4 inhibitor) in subjects with type 2 diabetes and renal impairment
por: Chacra, Antonio, et al.
Publicado: (2017)

A randomized, placebo‐ and sitagliptin‐controlled trial of the safety and efficacy of omarigliptin, a once‐weekly dipeptidyl peptidase‐4 inhibitor, in Japanese patients with type 2 diabetes
por: Gantz, Ira, et al.
Publicado: (2017)

Enhanced Chromatographic Determination of Nicotine in Human Plasma: Applied to Human Volunteers
por: Ayoub, Bassam M., et al.
Publicado: (2015)

Intranasal delivery in glioblastoma treatment: prospective molecular treatment modalities
por: Morales, Daniel E., et al.
Publicado: (2022)

Treatment Burden on Once-Weekly Omarigliptin Versus Daily Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes: Randomized Controlled Trial (ONWARD-DPP4 Study)
por: Ishii, Hitoshi, et al.
Publicado: (2023)

Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats
por: Dagda, Ruben K., et al.
Publicado: (2022)

Omarigliptin Protects the Integrity of the Blood–Brain Barrier After Intracerebral Hemorrhage in Mice
por: Zhang, Yan, et al.
Publicado: (2023)

Randomized clinical trial comparing the efficacy and safety of treatment with the once‐weekly dipeptidyl peptidase‐4 (DPP‐4) inhibitor omarigliptin or the once‐daily DPP‐4 inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled on metformin monotherapy
por: Goldenberg, Ronald, et al.
Publicado: (2017)

A randomized, placebo-controlled clinical trial evaluating the safety and efficacy of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus inadequately controlled by glimepiride and metformin
por: Lee, Seung-Hwan, et al.
Publicado: (2017)

DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic & Chemometric Approaches for Controlled Drug Delivery Systems
por: Arafa, Mona G., et al.
Publicado: (2017)

Effects of the Once-Weekly DPP4 Inhibitor Omarigliptin on Glycemic Control in Patients with Type 2 Diabetes Mellitus on Maintenance Hemodialysis: A 24-Week Open-Label, Multicenter Randomized Controlled Study
por: Yoshizawa, Yuta, et al.
Publicado: (2021)

Omarigliptin decreases inflammation and insulin resistance in a pleiotropic manner in patients with type 2 diabetes
por: Hattori, Sachiko
Publicado: (2020)

Comparative Liquid Chromatographic Study for Concurrent Determination of Canagliflozin and Metformin in Combined Tablets
por: Zaghary, Wafaa A., et al.
Publicado: (2017)

Comparative HPTLC study for simultaneous determination of ivabradine and metoprolol using UV and fluorescence detectors
por: Rizk, M., et al.
Publicado: (2023)

Beneficial effect of omarigliptin on diabetic patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis
por: Hattori, Sachiko, et al.
Publicado: (2021)

Metabolic and Cognitive Outcomes of Subchronic Once-Daily Intranasal Insulin Administration in Healthy Men
por: Ritze, Yvonne, et al.
Publicado: (2018)

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra
por: Mohamed, Ekram H., et al.
Publicado: (2017)

Development of Advanced Chemometric-Assisted Spectrophotometric Methods for the Determination of Cromolyn Sodium and Its Alkaline Degradation Products
por: El Zahar, Noha M., et al.
Publicado: (2020)

Comparing the protective effects of resveratrol, curcumin and sulforaphane against LPS/IFN-γ-mediated inflammation in doxorubicin-treated macrophages
por: Saleh, Haidy A., et al.
Publicado: (2021)

Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents
por: Arafa, Mona G., et al.
Publicado: (2018)

Efficacy and Patient Satisfaction of the Weekly DPP-4 Inhibitors Trelagliptin and Omarigliptin in 80 Japanese Patients with Type 2 Diabetes
por: Tosaki, Takahiro, et al.
Publicado: (2017)

Propolis-based niosomes as oromuco-adhesive films: A randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers
por: Arafa, Mona G., et al.
Publicado: (2018)

Publisher Correction: Propolis-based niosomes as oromuco-adhesive films: A randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers
por: Arafa, Mona G., et al.
Publicado: (2020)

Analytical quality-by-design approach for development and validation of HPLC method for the simultaneous estimation of omarigliptin, metformin, and ezetimibe: application to human plasma and dosage forms
por: Magdy, Galal, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8fn0t678rm04kcb28qc1vd7ate