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IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases

Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein. This transduces the signal of misfolded protein accumulation in the ER, named as ER stress, to the nucleus as “unfolded protein response...

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Detalles Bibliográficos
Autores principales:	Junjappa, Raghu Patil, Patil, Prakash, Bhattarai, Kashi Raj, Kim, Hyung-Ryong, Chae, Han-Jung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997832/ https://www.ncbi.nlm.nih.gov/pubmed/29928282 http://dx.doi.org/10.3389/fimmu.2018.01289

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