Temporal Expression of Mutant TDP-43 Correlates with Early Amyotrophic Lateral Sclerosis Phenotype and Motor Weakness

Background: Mutant transactive response DNA-binding protein (TDP-43) is closely correlated to the inherited form of amyotrophic lateral sclerosis (ALS). TDP-43 transgenic rats can reproduce the core phenotype of ALS and constitutive expression of TDP-43 caused postnatal death. Objective: The study a...

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Detalles Bibliográficos
Autores principales: Chen, Qihua, Zhou, Jinxia, Huang, Cao, Huang, Bo, Bi, Fangfang, Zhou, Hongxia, Xiao, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997843/
https://www.ncbi.nlm.nih.gov/pubmed/29313467
http://dx.doi.org/10.2174/1567202615666180109161541

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