In vitro studies data on anticancer activity of Caesalpinia sappan L. heartwood and leaf extracts on MCF7 and A549 cell lines

This article contains data on in vitro cytotoxicity activity of chloroform, methanolic and water extracts of leaf and heartwood of Caesalpinia sappan L. a medicinal plant against Breast cancer (MCF-7) and Lung cancer (A-549) cells. This data shows that Brazilin A, a natural bioactive compound in hea...

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Detalles Bibliográficos
Autores principales: Naik Bukke, Arunkumar, Nazneen Hadi, Fathima, Babu, K. Suresh, shankar, P. Chandramati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Agricultural and Biological Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997910/
https://www.ncbi.nlm.nih.gov/pubmed/29900385
http://dx.doi.org/10.1016/j.dib.2018.05.050
Descripción
Sumario:This article contains data on in vitro cytotoxicity activity of chloroform, methanolic and water extracts of leaf and heartwood of Caesalpinia sappan L. a medicinal plant against Breast cancer (MCF-7) and Lung cancer (A-549) cells. This data shows that Brazilin A, a natural bioactive compound in heartwood of Caesalpinia sappan L.induced cell death in breast cancer (MCF-7) cells. The therapeutic property was further proved by docking the Brazilin A molecule against BCL-2 protein (an apoptotic inhibitor) using auto dock tools.

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