Epitranscriptomics of cancer

The functional impact of modifications of cellular RNAs, including mRNAs, miRNAs and lncRNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported. Some RNA modifications pro...

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Detalles Bibliográficos
Autores principales: Tusup, Marina, Kundig, Thomas, Pascolo, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997933/
https://www.ncbi.nlm.nih.gov/pubmed/29900123
http://dx.doi.org/10.5306/wjco.v9.i3.42
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author Tusup, Marina
Kundig, Thomas
Pascolo, Steve
author_facet Tusup, Marina
Kundig, Thomas
Pascolo, Steve
author_sort Tusup, Marina
collection PubMed
description The functional impact of modifications of cellular RNAs, including mRNAs, miRNAs and lncRNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported. Some RNA modifications promote, while others decrease the growth and invasiveness of cancer. The present manuscript reviews the current knowledge on the potential impacts of N6-Methyladenosine, Pseudouridine, Inosine, 2’O-methylation or methylcytidine in cancer’s RNA. It also highlights the remaining questions and provides hints on research avenues and potential therapeutic applications, whereby modulating dynamic RNA modifications may be a new method to treat cancer.
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spelling pubmed-59979332018-06-13 Epitranscriptomics of cancer Tusup, Marina Kundig, Thomas Pascolo, Steve World J Clin Oncol Review The functional impact of modifications of cellular RNAs, including mRNAs, miRNAs and lncRNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported. Some RNA modifications promote, while others decrease the growth and invasiveness of cancer. The present manuscript reviews the current knowledge on the potential impacts of N6-Methyladenosine, Pseudouridine, Inosine, 2’O-methylation or methylcytidine in cancer’s RNA. It also highlights the remaining questions and provides hints on research avenues and potential therapeutic applications, whereby modulating dynamic RNA modifications may be a new method to treat cancer. Baishideng Publishing Group Inc 2018-06-10 2018-06-10 /pmc/articles/PMC5997933/ /pubmed/29900123 http://dx.doi.org/10.5306/wjco.v9.i3.42 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Tusup, Marina
Kundig, Thomas
Pascolo, Steve
Epitranscriptomics of cancer
title Epitranscriptomics of cancer
title_full Epitranscriptomics of cancer
title_fullStr Epitranscriptomics of cancer
title_full_unstemmed Epitranscriptomics of cancer
title_short Epitranscriptomics of cancer
title_sort epitranscriptomics of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997933/
https://www.ncbi.nlm.nih.gov/pubmed/29900123
http://dx.doi.org/10.5306/wjco.v9.i3.42
work_keys_str_mv AT tusupmarina epitranscriptomicsofcancer
AT kundigthomas epitranscriptomicsofcancer
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