A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA

Mitochondrial dysfunction is implicated in many neurodegenerative diseases including Parkinson’s disease (PD). Induced pluripotent stem cells (iPSCs) provide a unique cell model for studying neurological diseases. We have established a high-content assay that can simultaneously measure mitochondrial...

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Detalles Bibliográficos
Autores principales: Little, Daniel, Luft, Christin, Mosaku, Olukunbi, Lorvellec, Maëlle, Yao, Zhi, Paillusson, Sébastien, Kriston-Vizi, Janos, Gandhi, Sonia, Abramov, Andrey Y., Ketteler, Robin, Devine, Michael J., Gissen, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998042/
https://www.ncbi.nlm.nih.gov/pubmed/29899557
http://dx.doi.org/10.1038/s41598-018-27058-0

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