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Touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors
Soft touch possesses strong prosocial effects that facilitate social bonding and group cohesion in animals. Touch activates opioids (OP) and oxytocin (OXT), two neuromodulators involved in affiliative behaviors and social bonding. We examined whether touch serves as an unconditioned reward in affect...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998070/ https://www.ncbi.nlm.nih.gov/pubmed/29899398 http://dx.doi.org/10.1038/s41598-018-27199-2 |
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author | Fu, Yu Selcuk, Emre Moore, Sarah R. Depue, Richard A. |
author_facet | Fu, Yu Selcuk, Emre Moore, Sarah R. Depue, Richard A. |
author_sort | Fu, Yu |
collection | PubMed |
description | Soft touch possesses strong prosocial effects that facilitate social bonding and group cohesion in animals. Touch activates opioids (OP) and oxytocin (OXT), two neuromodulators involved in affiliative behaviors and social bonding. We examined whether touch serves as an unconditioned reward in affective conditioning of human faces, a basic process in social bonding, and whether this process is mediated by variation in mu-OP (OPRM1) and OXT (rs53576) receptor genes. Participants viewed affectively-neutral human faces, half of which were paired with a brief soft brushing on the forearm as an unconditioned stimulus (US). Paired and unpaired faces were rated for positive affective and sensory features of touch. Variation in OPRM1 but not rs53576 significantly modulated strength and development of conditioning, indicating that touch-induced mu-OP but not OXT activity provides rewarding properties of a US in conditioning. Implications for touch-induced mu-OP activity in normal and disordered conditioned social bonding are discussed. |
format | Online Article Text |
id | pubmed-5998070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59980702018-06-21 Touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors Fu, Yu Selcuk, Emre Moore, Sarah R. Depue, Richard A. Sci Rep Article Soft touch possesses strong prosocial effects that facilitate social bonding and group cohesion in animals. Touch activates opioids (OP) and oxytocin (OXT), two neuromodulators involved in affiliative behaviors and social bonding. We examined whether touch serves as an unconditioned reward in affective conditioning of human faces, a basic process in social bonding, and whether this process is mediated by variation in mu-OP (OPRM1) and OXT (rs53576) receptor genes. Participants viewed affectively-neutral human faces, half of which were paired with a brief soft brushing on the forearm as an unconditioned stimulus (US). Paired and unpaired faces were rated for positive affective and sensory features of touch. Variation in OPRM1 but not rs53576 significantly modulated strength and development of conditioning, indicating that touch-induced mu-OP but not OXT activity provides rewarding properties of a US in conditioning. Implications for touch-induced mu-OP activity in normal and disordered conditioned social bonding are discussed. Nature Publishing Group UK 2018-06-13 /pmc/articles/PMC5998070/ /pubmed/29899398 http://dx.doi.org/10.1038/s41598-018-27199-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Fu, Yu Selcuk, Emre Moore, Sarah R. Depue, Richard A. Touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors |
title | Touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors |
title_full | Touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors |
title_fullStr | Touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors |
title_full_unstemmed | Touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors |
title_short | Touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors |
title_sort | touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998070/ https://www.ncbi.nlm.nih.gov/pubmed/29899398 http://dx.doi.org/10.1038/s41598-018-27199-2 |
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