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Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat
It is well known that auditory experience during early development shapes response properties of auditory cortex (AC) neurons, influencing, for example, tonotopical arrangement, response thresholds and strength, or frequency selectivity. Here, we show that rearing rat pups in a complex acoustically...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998158/ https://www.ncbi.nlm.nih.gov/pubmed/30002673 http://dx.doi.org/10.1155/2018/5903720 |
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author | Bureš, Zbyněk Pysanenko, Kateryna Lindovský, Jiří Syka, Josef |
author_facet | Bureš, Zbyněk Pysanenko, Kateryna Lindovský, Jiří Syka, Josef |
author_sort | Bureš, Zbyněk |
collection | PubMed |
description | It is well known that auditory experience during early development shapes response properties of auditory cortex (AC) neurons, influencing, for example, tonotopical arrangement, response thresholds and strength, or frequency selectivity. Here, we show that rearing rat pups in a complex acoustically enriched environment leads to an increased reliability of responses of AC neurons, affecting both the rate and the temporal codes. For a repetitive stimulus, the neurons exhibit a lower spike count variance, indicating a more stable rate coding. At the level of individual spikes, the discharge patterns of individual neurons show a higher degree of similarity across stimulus repetitions. Furthermore, the neurons follow more precisely the temporal course of the stimulus, as manifested by improved phase-locking to temporally modulated sounds. The changes are persistent and present up to adulthood. The results document that besides basic alterations of receptive fields presented in our previous study, the acoustic environment during the critical period of postnatal development also leads to a decreased stochasticity and a higher reproducibility of neuronal spiking patterns. |
format | Online Article Text |
id | pubmed-5998158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59981582018-07-12 Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat Bureš, Zbyněk Pysanenko, Kateryna Lindovský, Jiří Syka, Josef Neural Plast Research Article It is well known that auditory experience during early development shapes response properties of auditory cortex (AC) neurons, influencing, for example, tonotopical arrangement, response thresholds and strength, or frequency selectivity. Here, we show that rearing rat pups in a complex acoustically enriched environment leads to an increased reliability of responses of AC neurons, affecting both the rate and the temporal codes. For a repetitive stimulus, the neurons exhibit a lower spike count variance, indicating a more stable rate coding. At the level of individual spikes, the discharge patterns of individual neurons show a higher degree of similarity across stimulus repetitions. Furthermore, the neurons follow more precisely the temporal course of the stimulus, as manifested by improved phase-locking to temporally modulated sounds. The changes are persistent and present up to adulthood. The results document that besides basic alterations of receptive fields presented in our previous study, the acoustic environment during the critical period of postnatal development also leads to a decreased stochasticity and a higher reproducibility of neuronal spiking patterns. Hindawi 2018-05-30 /pmc/articles/PMC5998158/ /pubmed/30002673 http://dx.doi.org/10.1155/2018/5903720 Text en Copyright © 2018 Zbyněk Bureš et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bureš, Zbyněk Pysanenko, Kateryna Lindovský, Jiří Syka, Josef Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat |
title | Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat |
title_full | Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat |
title_fullStr | Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat |
title_full_unstemmed | Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat |
title_short | Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat |
title_sort | acoustical enrichment during early development improves response reliability in the adult auditory cortex of the rat |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998158/ https://www.ncbi.nlm.nih.gov/pubmed/30002673 http://dx.doi.org/10.1155/2018/5903720 |
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