Cargando…

Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish

The 11q23 of the mixed lineage leukemia 1 (MLL1) gene plays a crucial role in early embryonic development and hematopoiesis. The MLL-AF9 fusion gene, resulting from chromosomal translocation, often leads to acute myeloid leukemia with poor prognosis. Here, we generated a zebrafish model expressing t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Jiaqi, Zhao, Lei, Wang, Gaoxiang, Li, Tongjuan, Li, Dan, Xu, Qian, Chen, Xing, Shang, Zhen, Wang, Jue, Zhou, Jianfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998191/ https://www.ncbi.nlm.nih.gov/pubmed/30003105 http://dx.doi.org/10.1155/2018/6705842

Ejemplares similares

Corrigendum to “Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish”
por: Tan, Jiaqi, et al.
Publicado: (2022)

Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells
por: Chiarella, Emanuela, et al.
Publicado: (2020)

The E3 ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia
por: Zhang, Kai, et al.
Publicado: (2023)

CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis
por: Sarrou, Evgenia, et al.
Publicado: (2020)

Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation
por: Barone, Cristiana, et al.
Publicado: (2023)

Integrated transcriptomic and epigenetic data analysis identifies aberrant expression of genes in acute myeloid leukemia with MLL-AF9 translocation
por: Wang, Fangce, et al.
Publicado: (2021)

Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells
por: Liu, Y, et al.
Publicado: (2014)

The mechanism of MYB transcriptional regulation by MLL-AF9 oncoprotein
por: Cao, Lu, et al.
Publicado: (2019)

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair
por: Castaño, Julio, et al.
Publicado: (2016)

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
por: Chen, Xinyue, et al.
Publicado: (2019)

TIFAB accelerates MLL-AF9−Induced acute myeloid leukemia through upregulation of HOXA9
por: Zhao, Jinming, et al.
Publicado: (2021)

Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation
por: Heuts, Branco M. H., et al.
Publicado: (2023)

Protocol to establish a stable MLL-AF9_AML mouse model
por: Lu, Jun, et al.
Publicado: (2022)

MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
por: Prange, K H M, et al.
Publicado: (2017)

Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C
por: Zhou, Kuangguo, et al.
Publicado: (2021)

The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae
por: Johannessen, Julie A., et al.
Publicado: (2023)

circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression
por: Huang, Wei, et al.
Publicado: (2019)

SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia
por: Chu, Yajing, et al.
Publicado: (2020)

Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis
por: Grigsby, Sierrah M., et al.
Publicado: (2021)

Publisher Correction: MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
por: Chen, Xinyue, et al.
Publicado: (2020)

314. Using CRISPR/Cas9 to dissect the regions of MLL/AF9 that are critical for myeloid immortalization
por: Yvanovich, Emma, et al.
Publicado: (2023)

ZNF521 Enhances MLL-AF9-Dependent Hematopoietic Stem Cell Transformation in Acute Myeloid Leukemias by Altering the Gene Expression Landscape †
por: Chiarella, Emanuela, et al.
Publicado: (2021)

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
por: Bueno, Clara, et al.
Publicado: (2019)

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes
por: Fleischmann, Katrin K, et al.
Publicado: (2014)

Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis
por: Bagislar, Sevgi, et al.
Publicado: (2016)

Bone marrow mesenchymal stem cells from infants with MLL-AF4(+) acute leukemia harbor and express the MLL-AF4 fusion gene
por: Menendez, Pablo, et al.
Publicado: (2009)

Stabilization of NF-κB-Inducing Kinase Suppresses MLL-AF9-Induced Acute Myeloid Leukemia
por: Xiu, Yan, et al.
Publicado: (2018)

Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLL-AF9 translocation
por: Wang, Fangce, et al.
Publicado: (2020)

Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations
por: Secker, Kathy-Ann, et al.
Publicado: (2020)

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9
por: Zhang, Li-shu, et al.
Publicado: (2018)

High-fat diet intensifies MLL-AF9-induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells
por: Hermetet, François, et al.
Publicado: (2020)

Peritoneal resident macrophages in mice with MLL-AF9-induced acute myeloid leukemia show an M2-like phenotype
por: Chen, Chong, et al.
Publicado: (2021)

Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL
por: Ahmad, K, et al.
Publicado: (2014)

Role of the bone marrow vascular niche in chemotherapy for MLL-AF9-induced acute myeloid leukemia
por: Xu, Chang, et al.
Publicado: (2023)

Extracellular Vesicles Expressing CD19 Antigen Improve Expansion and Efficacy of CD19-Targeted CAR-T Cells
por: Zhang, Yuanyuan, et al.
Publicado: (2023)

Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model
por: Liu, Qiang, et al.
Publicado: (2016)

Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited
por: Gué, Michaël, et al.
Publicado: (2006)

Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia
por: Gao, Yanan, et al.
Publicado: (2016)

P2X7 promotes the progression of MLL-AF9-induced acute myeloid leukemia by upregulation of Pbx3
por: Feng, Wenli, et al.
Publicado: (2020)

Isolated meningeal myeloid sarcoma with recurrent MLL-AF6 translocation: a case report
por: Wang, Chunyan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vflecui75romha38tdp8ptvoo5