Cargando…

Epithelial disruption: a new paradigm enabling human airway stem cell transplantation

BACKGROUND: Airway disease is a primary cause of morbidity and early mortality for patients with cystic fibrosis (CF). Cell transplantation therapy has proven successful for treating immune disorders and may have the potential to correct the airway disease phenotype associated with CF. Since in vivo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farrow, Nigel, Cmielewski, Patricia, Donnelley, Martin, Rout-Pitt, Nathan, Moodley, Yuben, Bertoncello, Ivan, Parsons, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998543/ https://www.ncbi.nlm.nih.gov/pubmed/29895311 http://dx.doi.org/10.1186/s13287-018-0911-4

Ejemplares similares

Breaching the Delivery Barrier: Chemical and Physical Airway Epithelium Disruption Strategies for Enhancing Lentiviral-Mediated Gene Therapy
por: McCarron, Alexandra, et al.
Publicado: (2021)

Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology
por: Rout-Pitt, Nathan, et al.
Publicado: (2018)

Repeat or single-dose lentiviral vector administration to mouse lungs? It’s all about the timing
por: Donnelley, Martin, et al.
Publicado: (2023)

Transduction of ferret airway epithelia using a pre-treatment and lentiviral gene vector
por: Cmielewski, Patricia, et al.
Publicado: (2014)

Airway gene transfer in a non-human primate: Lentiviral gene expression in marmoset lungs
por: Farrow, N., et al.
Publicado: (2013)

Effective viral-mediated lung gene therapy: is airway surface preparation necessary?
por: McCarron, Alexandra, et al.
Publicado: (2022)

Improved in-vivo airway gene transfer via magnetic-guidance, with protocol development informed by synchrotron imaging
por: Donnelley, Martin, et al.
Publicado: (2022)

Assessment of Lentiviral Vector Mediated CFTR Correction in Mice Using an Improved Rapid in vivo Nasal Potential Difference Measurement Protocol
por: Cmielewski, P., et al.
Publicado: (2021)

To bead or not to bead: A review of Pseudomonas aeruginosa lung infection models for cystic fibrosis
por: Reyne, Nicole, et al.
Publicado: (2023)

Single-Dose Lentiviral Mediated Gene Therapy Recovers CFTR Function in Cystic Fibrosis Knockout Rats
por: Reyne, Nicole, et al.
Publicado: (2021)

Lysophosphatidylcholine as an adjuvant for lentiviral vector mediated gene transfer to airway epithelium: effect of acyl chain length
por: Cmielewski, Patricia, et al.
Publicado: (2010)

Large-scale production of lentiviral vectors using multilayer cell factories
por: Rout-Pitt, Nathan, et al.
Publicado: (2018)

Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo
por: Donnelley, Martin, et al.
Publicado: (2014)

CORRIGENDUM: Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo
por: Donnelley, Martin, et al.
Publicado: (2014)

Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex
por: Shrestha, Nirajan, et al.
Publicado: (2022)

Airway disease phenotypes in animal models of cystic fibrosis
por: McCarron, Alexandra, et al.
Publicado: (2018)

High-resolution mucociliary transport measurement in live excised large animal trachea using synchrotron X-ray imaging
por: Donnelley, Martin, et al.
Publicado: (2017)

Methods for dynamic synchrotron X-ray respiratory imaging in live animals
por: Morgan, Kaye Susannah, et al.
Publicado: (2020)

A high COPD assessment test score may predict anxiety in COPD
por: Harryanto, Hilman, et al.
Publicado: (2018)

Treatment of Cystic Fibrosis: From Gene- to Cell-Based Therapies
por: Allan, Katelin M., et al.
Publicado: (2021)

Induced pluripotent stem cell-derived lung alveolar epithelial type II cells reduce damage in bleomycin-induced lung fibrosis
por: Alvarez-Palomo, Belén, et al.
Publicado: (2020)

Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis
por: Shrestha, Nirajan, et al.
Publicado: (2023)

Measuring Airway Surface Liquid Depth in Ex Vivo Mouse Airways by X-Ray Imaging for the Assessment of Cystic Fibrosis Airway Therapies
por: Morgan, Kaye S., et al.
Publicado: (2013)

Human Metapneumovirus Glycoprotein G Disrupts Mitochondrial Signaling in Airway Epithelial Cells
por: Bao, Xiaoyong, et al.
Publicado: (2013)

Standardizing Zebrafish Behavioral Paradigms Across Life Stages: An Effort Towards Translational Pharmacology
por: Petersen, Barbara Dutra, et al.
Publicado: (2022)

Avasimibe Alleviates Disruption of the Airway Epithelial Barrier by Suppressing the Wnt/β-Catenin Signaling Pathway
por: Zhou, Zicong, et al.
Publicado: (2022)

Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin
por: Gao, Nannan, et al.
Publicado: (2022)

Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function
por: Hudock, K. M., et al.
Publicado: (2023)

Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium
por: McCormack, Natasha, et al.
Publicado: (2013)

Transcriptional profiling of circulating mononuclear cells from patients with chronic obstructive pulmonary disease receiving mesenchymal stromal cell infusions
por: Armitage, Jesse D., et al.
Publicado: (2021)

Gene Therapy for Cystic Fibrosis Lung Disease: Overcoming the Barriers to Translation to the Clinic
por: Donnelley, Martin, et al.
Publicado: (2018)

Disruption of the Molecular Regulation of Mitochondrial Metabolism in Airway and Lung Epithelial Cells by Cigarette Smoke: Are Aldehydes the Culprit?
por: Tulen, Christy B. M., et al.
Publicado: (2023)

Differentiated transplant derived airway epithelial cell cytokine secretion is not regulated by cyclosporine
por: Floreth, Timothy, et al.
Publicado: (2011)

Airway epithelial stem cell chimerism in cystic fibrosis lung transplant recipients
por: Hayes, Don, et al.
Publicado: (2021)

Quantification of heterogeneity in lung disease with image-based pulmonary function testing
por: Stahr, Charlene S., et al.
Publicado: (2016)

Backprojection Wiener deconvolution for computed tomographic reconstruction
por: Wang, Zhenglin, et al.
Publicado: (2018)

Epithelial disruption drives mesendoderm differentiation in human pluripotent stem cells by enabling TGF-β protein sensing
por: Legier, Thomas, et al.
Publicado: (2023)

Tight junction disruption by cadmium in an in vitro human airway tissue model
por: Cao, Xuefei, et al.
Publicado: (2015)

Cleavage of E-cadherin by porcine respiratory bacterial pathogens facilitates airway epithelial barrier disruption and bacterial paracellular transmigration
por: Cao, Qi, et al.
Publicado: (2021)

Stimulus-dependent dissociation between XB130 and Tks5 scaffold proteins promotes airway epithelial cell migration
por: Moodley, Serisha, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_q8vsg83g8dh17oh77bf7b7nuac