Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

BACKGROUND: Skeletal muscle atrophy is a common feature of numerous chronic pathologies and is correlated with patient mortality. The REDD1 protein is currently recognized as a negative regulator of muscle mass through inhibition of the Akt/mTORC1 signaling pathway. REDD1 expression is notably induc...

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Detalles Bibliográficos
Autores principales: Britto, Florian A., Cortade, Fabienne, Belloum, Yassine, Blaquière, Marine, Gallot, Yann S., Docquier, Aurélie, Pagano, Allan F., Jublanc, Elodie, Bendridi, Nadia, Koechlin-Ramonatxo, Christelle, Chabi, Béatrice, Francaux, Marc, Casas, François, Freyssenet, Damien, Rieusset, Jennifer, Giorgetti-Peraldi, Sophie, Carnac, Gilles, Ollendorff, Vincent, Favier, François B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998563/
https://www.ncbi.nlm.nih.gov/pubmed/29895328
http://dx.doi.org/10.1186/s12915-018-0525-4

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