Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis

Histone H3 lysine 9 (H3K9) methylation is unevenly distributed in mammalian chromosomes. However, the molecular mechanism controlling the uneven distribution and its biological significance remain to be elucidated. Here, we show that JMJD1A and JMJD1B preferentially target H3K9 demethylation of gene...

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Detalles Bibliográficos
Autores principales: Kuroki, Shunsuke, Nakai, Yuji, Maeda, Ryo, Okashita, Naoki, Akiyoshi, Mika, Yamaguchi, Yutaro, Kitano, Satsuki, Miyachi, Hitoshi, Nakato, Ryuichiro, Ichiyanagi, Kenji, Shirahige, Katsuhiko, Kimura, Hiroshi, Shinkai, Yoichi, Tachibana, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998703/
https://www.ncbi.nlm.nih.gov/pubmed/29526734
http://dx.doi.org/10.1016/j.stemcr.2018.02.002

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