Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature

Monoclonal gammopathy of renal significance (MGRS) can present with myriad of morphological features. We report a case of MGRS in a 46-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. Renal biopsy showed amorphous eosinophilic periodic acid–Schiff positive deposit...

Descripción completa

Detalles Bibliográficos
Autores principales: Goli, R., Raju, Sree Bhushan, Uppin, M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998724/
https://www.ncbi.nlm.nih.gov/pubmed/29962675
http://dx.doi.org/10.4103/ijn.IJN_166_16
_version_ 1783331285262925824
author Goli, R.
Raju, Sree Bhushan
Uppin, M. S.
author_facet Goli, R.
Raju, Sree Bhushan
Uppin, M. S.
author_sort Goli, R.
collection PubMed
description Monoclonal gammopathy of renal significance (MGRS) can present with myriad of morphological features. We report a case of MGRS in a 46-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. Renal biopsy showed amorphous eosinophilic periodic acid–Schiff positive deposits in capillary loops and lamda light chain positivity on immunofluorescence, suggestive of cyoglobulinemic glomerulonephritis. Serum cryoglobulins were positive. Serum immunoelectrophoresis and immunofixation showed a M band of 0.5 g/dl of IgG lambda type. Bone marrow showed 8% of plasma cells which confirmed the diagnosis of MGRS.
format Online
Article
Text
id pubmed-5998724
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-59987242018-06-29 Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature Goli, R. Raju, Sree Bhushan Uppin, M. S. Indian J Nephrol Case Report Monoclonal gammopathy of renal significance (MGRS) can present with myriad of morphological features. We report a case of MGRS in a 46-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. Renal biopsy showed amorphous eosinophilic periodic acid–Schiff positive deposits in capillary loops and lamda light chain positivity on immunofluorescence, suggestive of cyoglobulinemic glomerulonephritis. Serum cryoglobulins were positive. Serum immunoelectrophoresis and immunofixation showed a M band of 0.5 g/dl of IgG lambda type. Bone marrow showed 8% of plasma cells which confirmed the diagnosis of MGRS. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5998724/ /pubmed/29962675 http://dx.doi.org/10.4103/ijn.IJN_166_16 Text en Copyright: © 2018 Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Goli, R.
Raju, Sree Bhushan
Uppin, M. S.
Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature
title Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature
title_full Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature
title_fullStr Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature
title_full_unstemmed Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature
title_short Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature
title_sort monoclonal gammopathy of renal significance presenting as cryoglobulinemic glomerulonephritis: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998724/
https://www.ncbi.nlm.nih.gov/pubmed/29962675
http://dx.doi.org/10.4103/ijn.IJN_166_16
work_keys_str_mv AT golir monoclonalgammopathyofrenalsignificancepresentingascryoglobulinemicglomerulonephritisacasereportandreviewofliterature
AT rajusreebhushan monoclonalgammopathyofrenalsignificancepresentingascryoglobulinemicglomerulonephritisacasereportandreviewofliterature
AT uppinms monoclonalgammopathyofrenalsignificancepresentingascryoglobulinemicglomerulonephritisacasereportandreviewofliterature

Ejemplares similares