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The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis

BACKGROUND: The aim of this study was to find a simple and easily accessible scoring system that could predict the development of sepsis in the preseptic period. MATERIAL/METHODS: The study included 161 patients with a basal sequential organ failure assessment (SOFA) value of 2 or more. The sepsis g...

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Autores principales: Boran, Ömer Faruk, Yazar, Fatih Mehmet, Boran, Maruf, Urfalıoğlu, Aykut, Bakacak, Zeyneb, Yıldız, Mürşide, Gül, Fethi, Güler, Selma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998727/
https://www.ncbi.nlm.nih.gov/pubmed/29804126
http://dx.doi.org/10.12659/MSM.907687
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author Boran, Ömer Faruk
Yazar, Fatih Mehmet
Boran, Maruf
Urfalıoğlu, Aykut
Bakacak, Zeyneb
Yıldız, Mürşide
Gül, Fethi
Güler, Selma
author_facet Boran, Ömer Faruk
Yazar, Fatih Mehmet
Boran, Maruf
Urfalıoğlu, Aykut
Bakacak, Zeyneb
Yıldız, Mürşide
Gül, Fethi
Güler, Selma
author_sort Boran, Ömer Faruk
collection PubMed
description BACKGROUND: The aim of this study was to find a simple and easily accessible scoring system that could predict the development of sepsis in the preseptic period. MATERIAL/METHODS: The study included 161 patients with a basal sequential organ failure assessment (SOFA) value of 2 or more. The sepsis group (n=83) comprised patients with infection reported in culture results; the control group (n=78) comprised patients not showing evidence of infection in blood, urine, and phlegm cultures; samples were taken on three consecutive days. RESULTS: The patients in both groups were divided into subgroups of non-survivor and survivor patients. The preseptic and septic SOFA score, neutrophil lymphocyte ratio (NLR), and procalcitonin (PRC) and lactate (Lac) values were determined to be statistically significantly higher in the sepsis group than in the control group. When the values related to sepsis were examined, a strong relationship was determined between sepsis and SOFA score, PRC values, and Lac values in the preseptic period and a weak relationship with NLR. In the model formed using multiple regression analysis with defined cutoff values for the preseptic and the septic periods, we found that in the septic period, a diagnosis of sepsis could be made with 83.8% accuracy. The diagnostic value of the same parameters evaluated in the preseptic period was 77.9%. CONCLUSIONS: The diagnostic value of the combination of Lac, PRC, SOFA, and NLR were found to be similar in the preseptic period as the sepsis period; thus these combined values could safely be used for the early diagnosis of sepsis.
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spelling pubmed-59987272018-06-14 The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis Boran, Ömer Faruk Yazar, Fatih Mehmet Boran, Maruf Urfalıoğlu, Aykut Bakacak, Zeyneb Yıldız, Mürşide Gül, Fethi Güler, Selma Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to find a simple and easily accessible scoring system that could predict the development of sepsis in the preseptic period. MATERIAL/METHODS: The study included 161 patients with a basal sequential organ failure assessment (SOFA) value of 2 or more. The sepsis group (n=83) comprised patients with infection reported in culture results; the control group (n=78) comprised patients not showing evidence of infection in blood, urine, and phlegm cultures; samples were taken on three consecutive days. RESULTS: The patients in both groups were divided into subgroups of non-survivor and survivor patients. The preseptic and septic SOFA score, neutrophil lymphocyte ratio (NLR), and procalcitonin (PRC) and lactate (Lac) values were determined to be statistically significantly higher in the sepsis group than in the control group. When the values related to sepsis were examined, a strong relationship was determined between sepsis and SOFA score, PRC values, and Lac values in the preseptic period and a weak relationship with NLR. In the model formed using multiple regression analysis with defined cutoff values for the preseptic and the septic periods, we found that in the septic period, a diagnosis of sepsis could be made with 83.8% accuracy. The diagnostic value of the same parameters evaluated in the preseptic period was 77.9%. CONCLUSIONS: The diagnostic value of the combination of Lac, PRC, SOFA, and NLR were found to be similar in the preseptic period as the sepsis period; thus these combined values could safely be used for the early diagnosis of sepsis. International Scientific Literature, Inc. 2018-05-27 /pmc/articles/PMC5998727/ /pubmed/29804126 http://dx.doi.org/10.12659/MSM.907687 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Boran, Ömer Faruk
Yazar, Fatih Mehmet
Boran, Maruf
Urfalıoğlu, Aykut
Bakacak, Zeyneb
Yıldız, Mürşide
Gül, Fethi
Güler, Selma
The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis
title The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis
title_full The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis
title_fullStr The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis
title_full_unstemmed The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis
title_short The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis
title_sort preseptic period and inflammatory markers in the prediction of the course of sepsis
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998727/
https://www.ncbi.nlm.nih.gov/pubmed/29804126
http://dx.doi.org/10.12659/MSM.907687
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