Cargando…
The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis
BACKGROUND: The aim of this study was to find a simple and easily accessible scoring system that could predict the development of sepsis in the preseptic period. MATERIAL/METHODS: The study included 161 patients with a basal sequential organ failure assessment (SOFA) value of 2 or more. The sepsis g...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998727/ https://www.ncbi.nlm.nih.gov/pubmed/29804126 http://dx.doi.org/10.12659/MSM.907687 |
_version_ | 1783331286018949120 |
---|---|
author | Boran, Ömer Faruk Yazar, Fatih Mehmet Boran, Maruf Urfalıoğlu, Aykut Bakacak, Zeyneb Yıldız, Mürşide Gül, Fethi Güler, Selma |
author_facet | Boran, Ömer Faruk Yazar, Fatih Mehmet Boran, Maruf Urfalıoğlu, Aykut Bakacak, Zeyneb Yıldız, Mürşide Gül, Fethi Güler, Selma |
author_sort | Boran, Ömer Faruk |
collection | PubMed |
description | BACKGROUND: The aim of this study was to find a simple and easily accessible scoring system that could predict the development of sepsis in the preseptic period. MATERIAL/METHODS: The study included 161 patients with a basal sequential organ failure assessment (SOFA) value of 2 or more. The sepsis group (n=83) comprised patients with infection reported in culture results; the control group (n=78) comprised patients not showing evidence of infection in blood, urine, and phlegm cultures; samples were taken on three consecutive days. RESULTS: The patients in both groups were divided into subgroups of non-survivor and survivor patients. The preseptic and septic SOFA score, neutrophil lymphocyte ratio (NLR), and procalcitonin (PRC) and lactate (Lac) values were determined to be statistically significantly higher in the sepsis group than in the control group. When the values related to sepsis were examined, a strong relationship was determined between sepsis and SOFA score, PRC values, and Lac values in the preseptic period and a weak relationship with NLR. In the model formed using multiple regression analysis with defined cutoff values for the preseptic and the septic periods, we found that in the septic period, a diagnosis of sepsis could be made with 83.8% accuracy. The diagnostic value of the same parameters evaluated in the preseptic period was 77.9%. CONCLUSIONS: The diagnostic value of the combination of Lac, PRC, SOFA, and NLR were found to be similar in the preseptic period as the sepsis period; thus these combined values could safely be used for the early diagnosis of sepsis. |
format | Online Article Text |
id | pubmed-5998727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59987272018-06-14 The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis Boran, Ömer Faruk Yazar, Fatih Mehmet Boran, Maruf Urfalıoğlu, Aykut Bakacak, Zeyneb Yıldız, Mürşide Gül, Fethi Güler, Selma Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to find a simple and easily accessible scoring system that could predict the development of sepsis in the preseptic period. MATERIAL/METHODS: The study included 161 patients with a basal sequential organ failure assessment (SOFA) value of 2 or more. The sepsis group (n=83) comprised patients with infection reported in culture results; the control group (n=78) comprised patients not showing evidence of infection in blood, urine, and phlegm cultures; samples were taken on three consecutive days. RESULTS: The patients in both groups were divided into subgroups of non-survivor and survivor patients. The preseptic and septic SOFA score, neutrophil lymphocyte ratio (NLR), and procalcitonin (PRC) and lactate (Lac) values were determined to be statistically significantly higher in the sepsis group than in the control group. When the values related to sepsis were examined, a strong relationship was determined between sepsis and SOFA score, PRC values, and Lac values in the preseptic period and a weak relationship with NLR. In the model formed using multiple regression analysis with defined cutoff values for the preseptic and the septic periods, we found that in the septic period, a diagnosis of sepsis could be made with 83.8% accuracy. The diagnostic value of the same parameters evaluated in the preseptic period was 77.9%. CONCLUSIONS: The diagnostic value of the combination of Lac, PRC, SOFA, and NLR were found to be similar in the preseptic period as the sepsis period; thus these combined values could safely be used for the early diagnosis of sepsis. International Scientific Literature, Inc. 2018-05-27 /pmc/articles/PMC5998727/ /pubmed/29804126 http://dx.doi.org/10.12659/MSM.907687 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Boran, Ömer Faruk Yazar, Fatih Mehmet Boran, Maruf Urfalıoğlu, Aykut Bakacak, Zeyneb Yıldız, Mürşide Gül, Fethi Güler, Selma The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis |
title | The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis |
title_full | The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis |
title_fullStr | The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis |
title_full_unstemmed | The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis |
title_short | The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis |
title_sort | preseptic period and inflammatory markers in the prediction of the course of sepsis |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998727/ https://www.ncbi.nlm.nih.gov/pubmed/29804126 http://dx.doi.org/10.12659/MSM.907687 |
work_keys_str_mv | AT boranomerfaruk thepresepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT yazarfatihmehmet thepresepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT boranmaruf thepresepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT urfalıogluaykut thepresepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT bakacakzeyneb thepresepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT yıldızmurside thepresepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT gulfethi thepresepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT gulerselma thepresepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT boranomerfaruk presepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT yazarfatihmehmet presepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT boranmaruf presepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT urfalıogluaykut presepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT bakacakzeyneb presepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT yıldızmurside presepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT gulfethi presepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis AT gulerselma presepticperiodandinflammatorymarkersinthepredictionofthecourseofsepsis |