The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer

Toll-like receptor (TLR) 4 is expressed on normal and malignant prostate epithelial cells. The TLR4 and its downstream signaling pathways mediate innate immune responses in the host against invading pathogens. However, multiple lines of evidence shows that TLR4 expression is increased in prostate ti...

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Detalles Bibliográficos
Autores principales: Ou, Tongwen, Lilly, Michael, Jiang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998742/
https://www.ncbi.nlm.nih.gov/pubmed/29928275
http://dx.doi.org/10.3389/fimmu.2018.01188
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author Ou, Tongwen
Lilly, Michael
Jiang, Wei
author_facet Ou, Tongwen
Lilly, Michael
Jiang, Wei
author_sort Ou, Tongwen
collection PubMed
description Toll-like receptor (TLR) 4 is expressed on normal and malignant prostate epithelial cells. The TLR4 and its downstream signaling pathways mediate innate immune responses in the host against invading pathogens. However, multiple lines of evidence shows that TLR4 expression is increased in prostate tissues from prostate cancer patients, and altered TLR4 signals may promote cancer development, as well as antitumor effects. In this review, we have summarized key features of the TLR4 signaling pathway and its associated immune responses and focused on the pathologic role of TLR4 in prostate carcinogenesis and tumor progression.
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spelling pubmed-59987422018-06-20 The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer Ou, Tongwen Lilly, Michael Jiang, Wei Front Immunol Immunology Toll-like receptor (TLR) 4 is expressed on normal and malignant prostate epithelial cells. The TLR4 and its downstream signaling pathways mediate innate immune responses in the host against invading pathogens. However, multiple lines of evidence shows that TLR4 expression is increased in prostate tissues from prostate cancer patients, and altered TLR4 signals may promote cancer development, as well as antitumor effects. In this review, we have summarized key features of the TLR4 signaling pathway and its associated immune responses and focused on the pathologic role of TLR4 in prostate carcinogenesis and tumor progression. Frontiers Media S.A. 2018-06-06 /pmc/articles/PMC5998742/ /pubmed/29928275 http://dx.doi.org/10.3389/fimmu.2018.01188 Text en Copyright © 2018 Ou, Lilly and Jiang. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ou, Tongwen
Lilly, Michael
Jiang, Wei
The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer
title The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer
title_full The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer
title_fullStr The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer
title_full_unstemmed The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer
title_short The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer
title_sort pathologic role of toll-like receptor 4 in prostate cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998742/
https://www.ncbi.nlm.nih.gov/pubmed/29928275
http://dx.doi.org/10.3389/fimmu.2018.01188
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