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Individual and contextual risk factors for chikungunya virus infection: the SEROCHIK cross-sectional population-based study
The purpose of the study was to weigh the community burden of chikungunya determinants on Reunion island. Risk factors were investigated within a subset of 2101 adult persons from a population-based cross-sectional serosurvey, using Poisson regression models for dichotomous outcomes. Design-based ri...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998769/ https://www.ncbi.nlm.nih.gov/pubmed/29720285 http://dx.doi.org/10.1017/S0950268818000341 |
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author | Fred, A. Fianu, A. Béral, M. Guernier, V. Sissoko, D. Méchain, M. Michault, A. Boisson, V. Gaüzère, B.-A. Favier, F. Malvy, D. Gérardin, P. |
author_facet | Fred, A. Fianu, A. Béral, M. Guernier, V. Sissoko, D. Méchain, M. Michault, A. Boisson, V. Gaüzère, B.-A. Favier, F. Malvy, D. Gérardin, P. |
author_sort | Fred, A. |
collection | PubMed |
description | The purpose of the study was to weigh the community burden of chikungunya determinants on Reunion island. Risk factors were investigated within a subset of 2101 adult persons from a population-based cross-sectional serosurvey, using Poisson regression models for dichotomous outcomes. Design-based risk ratios and population attributable fractions (PAF) were generated distinguishing individual and contextual (i.e. that affect individuals collectively) determinants. The disease burden attributable to contextual determinants was twice that of individual determinants (overall PAF value 89.5% vs. 44.1%). In a model regrouping both categories of determinants, the independent risk factors were by decreasing PAF values: an interaction term between the reporting of a chikungunya history in the neighbourhood and individual house (PAF 45.9%), a maximal temperature of the month preceding the infection higher than 28.5 °C (PAF 25.7%), a socio-economically disadvantaged neighbourhood (PAF 19.0%), altitude of dwelling (PAF 13.1%), cumulated rainfalls of the month preceding the infection higher than 65 mm (PAF 12.6%), occupational inactivity (PAF 11.6%), poor knowledge on chikungunya transmission (PAF 7.3%) and obesity/overweight (PAF 5.2%). Taken together, these covariates and their underlying causative factors uncovered 80.8% of chikungunya at population level. Our findings lend support to a major role of contextual risk factors in chikungunya virus outbreaks. |
format | Online Article Text |
id | pubmed-5998769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59987692018-06-18 Individual and contextual risk factors for chikungunya virus infection: the SEROCHIK cross-sectional population-based study Fred, A. Fianu, A. Béral, M. Guernier, V. Sissoko, D. Méchain, M. Michault, A. Boisson, V. Gaüzère, B.-A. Favier, F. Malvy, D. Gérardin, P. Epidemiol Infect Original Paper The purpose of the study was to weigh the community burden of chikungunya determinants on Reunion island. Risk factors were investigated within a subset of 2101 adult persons from a population-based cross-sectional serosurvey, using Poisson regression models for dichotomous outcomes. Design-based risk ratios and population attributable fractions (PAF) were generated distinguishing individual and contextual (i.e. that affect individuals collectively) determinants. The disease burden attributable to contextual determinants was twice that of individual determinants (overall PAF value 89.5% vs. 44.1%). In a model regrouping both categories of determinants, the independent risk factors were by decreasing PAF values: an interaction term between the reporting of a chikungunya history in the neighbourhood and individual house (PAF 45.9%), a maximal temperature of the month preceding the infection higher than 28.5 °C (PAF 25.7%), a socio-economically disadvantaged neighbourhood (PAF 19.0%), altitude of dwelling (PAF 13.1%), cumulated rainfalls of the month preceding the infection higher than 65 mm (PAF 12.6%), occupational inactivity (PAF 11.6%), poor knowledge on chikungunya transmission (PAF 7.3%) and obesity/overweight (PAF 5.2%). Taken together, these covariates and their underlying causative factors uncovered 80.8% of chikungunya at population level. Our findings lend support to a major role of contextual risk factors in chikungunya virus outbreaks. Cambridge University Press 2018-06 2018-05-03 /pmc/articles/PMC5998769/ /pubmed/29720285 http://dx.doi.org/10.1017/S0950268818000341 Text en © Cambridge University Press 2018 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Fred, A. Fianu, A. Béral, M. Guernier, V. Sissoko, D. Méchain, M. Michault, A. Boisson, V. Gaüzère, B.-A. Favier, F. Malvy, D. Gérardin, P. Individual and contextual risk factors for chikungunya virus infection: the SEROCHIK cross-sectional population-based study |
title | Individual and contextual risk factors for chikungunya virus infection: the SEROCHIK cross-sectional population-based study |
title_full | Individual and contextual risk factors for chikungunya virus infection: the SEROCHIK cross-sectional population-based study |
title_fullStr | Individual and contextual risk factors for chikungunya virus infection: the SEROCHIK cross-sectional population-based study |
title_full_unstemmed | Individual and contextual risk factors for chikungunya virus infection: the SEROCHIK cross-sectional population-based study |
title_short | Individual and contextual risk factors for chikungunya virus infection: the SEROCHIK cross-sectional population-based study |
title_sort | individual and contextual risk factors for chikungunya virus infection: the serochik cross-sectional population-based study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998769/ https://www.ncbi.nlm.nih.gov/pubmed/29720285 http://dx.doi.org/10.1017/S0950268818000341 |
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