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Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons

The brain of Down syndrome (DS) patients exhibits fewer interneurons in the cerebral cortex, but its underlying mechanism remains unknown. By morphometric analysis of cortical interneurons generated from DS and euploid induced pluripotent stem cells (iPSCs), we found that DS GABA neurons are smaller...

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Detalles Bibliográficos
Autores principales:	Huo, Hai-Qin, Qu, Zhuang-Yin, Yuan, Fang, Ma, Lixiang, Yao, Lin, Xu, Min, Hu, Yao, Ji, Jing, Bhattacharyya, Anita, Zhang, Su-Chun, Liu, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998838/ https://www.ncbi.nlm.nih.gov/pubmed/29526735 http://dx.doi.org/10.1016/j.stemcr.2018.02.001

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