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Optogenetic regulation of transcription

Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to transduce the...

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Autores principales: Polesskaya, Oksana, Baranova, Ancha, Bui, Sarah, Kondratev, Nikolai, Kananykhina, Evgeniya, Nazarenko, Olga, Shapiro, Tatyana, Nardia, Frances Barg, Kornienko, Vladimir, Chandhoke, Vikas, Stadler, Istvan, Lanzafame, Raymond, Myakishev-Rempel, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998900/
https://www.ncbi.nlm.nih.gov/pubmed/29745855
http://dx.doi.org/10.1186/s12868-018-0411-6
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author Polesskaya, Oksana
Baranova, Ancha
Bui, Sarah
Kondratev, Nikolai
Kananykhina, Evgeniya
Nazarenko, Olga
Shapiro, Tatyana
Nardia, Frances Barg
Kornienko, Vladimir
Chandhoke, Vikas
Stadler, Istvan
Lanzafame, Raymond
Myakishev-Rempel, Max
author_facet Polesskaya, Oksana
Baranova, Ancha
Bui, Sarah
Kondratev, Nikolai
Kananykhina, Evgeniya
Nazarenko, Olga
Shapiro, Tatyana
Nardia, Frances Barg
Kornienko, Vladimir
Chandhoke, Vikas
Stadler, Istvan
Lanzafame, Raymond
Myakishev-Rempel, Max
author_sort Polesskaya, Oksana
collection PubMed
description Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to transduce the signal to regulate gene transcription, and its possible use in medicine. One of the problems with existing gene therapies is that they could remain active indefinitely while not allowing regulated transgene production on demand. Optogenetic regulation of transcription (ORT) could potentially be used to regulate the production of a biological drug in situ, by repeatedly applying light to the tissue, and inducing expression of therapeutic transgenes when needed. Red and near infrared wavelengths, which are capable of penetration into tissues, have potential for therapeutic applications. Existing ORT systems are reviewed herein with these considerations in mind.
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spelling pubmed-59989002018-06-25 Optogenetic regulation of transcription Polesskaya, Oksana Baranova, Ancha Bui, Sarah Kondratev, Nikolai Kananykhina, Evgeniya Nazarenko, Olga Shapiro, Tatyana Nardia, Frances Barg Kornienko, Vladimir Chandhoke, Vikas Stadler, Istvan Lanzafame, Raymond Myakishev-Rempel, Max BMC Neurosci Review Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to transduce the signal to regulate gene transcription, and its possible use in medicine. One of the problems with existing gene therapies is that they could remain active indefinitely while not allowing regulated transgene production on demand. Optogenetic regulation of transcription (ORT) could potentially be used to regulate the production of a biological drug in situ, by repeatedly applying light to the tissue, and inducing expression of therapeutic transgenes when needed. Red and near infrared wavelengths, which are capable of penetration into tissues, have potential for therapeutic applications. Existing ORT systems are reviewed herein with these considerations in mind. BioMed Central 2018-04-19 /pmc/articles/PMC5998900/ /pubmed/29745855 http://dx.doi.org/10.1186/s12868-018-0411-6 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Polesskaya, Oksana
Baranova, Ancha
Bui, Sarah
Kondratev, Nikolai
Kananykhina, Evgeniya
Nazarenko, Olga
Shapiro, Tatyana
Nardia, Frances Barg
Kornienko, Vladimir
Chandhoke, Vikas
Stadler, Istvan
Lanzafame, Raymond
Myakishev-Rempel, Max
Optogenetic regulation of transcription
title Optogenetic regulation of transcription
title_full Optogenetic regulation of transcription
title_fullStr Optogenetic regulation of transcription
title_full_unstemmed Optogenetic regulation of transcription
title_short Optogenetic regulation of transcription
title_sort optogenetic regulation of transcription
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998900/
https://www.ncbi.nlm.nih.gov/pubmed/29745855
http://dx.doi.org/10.1186/s12868-018-0411-6
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