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Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population

Osteoarthritis (OA) is the most common degenerative disease affecting articular cartilage. Some studies indicate that tumor necrosis factor alpha (TNF-α) gene rs1800629 polymorphism was associated with OA risk among Caucasian populations. To examine the role of this candidate gene in Asian populatio...

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Detalles Bibliográficos
Autores principales: Chen, Jie, Wu, Yu, Yu, Jiannong, Shen, Jinming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999064/
https://www.ncbi.nlm.nih.gov/pubmed/29846433
http://dx.doi.org/10.1590/1414-431X20187311
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author Chen, Jie
Wu, Yu
Yu, Jiannong
Shen, Jinming
author_facet Chen, Jie
Wu, Yu
Yu, Jiannong
Shen, Jinming
author_sort Chen, Jie
collection PubMed
description Osteoarthritis (OA) is the most common degenerative disease affecting articular cartilage. Some studies indicate that tumor necrosis factor alpha (TNF-α) gene rs1800629 polymorphism was associated with OA risk among Caucasian populations. To examine the role of this candidate gene in Asian populations, we conducted a hospital-based case-control study involving 257 knee OA patients and 305 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan(™) kit. Our study indicated that the AA genotype of TNF-α rs1800629 polymorphism was associated with increased risk of OA. Subsequently, we conducted a meta-analysis and found that rs1800629 polymorphism increased the risk of OA in the recessive and homozygous models. Stratification analysis of ethnicity also obtained a significant association among Asian populations. In conclusion, TNF-α rs1800629 polymorphism confers susceptibility to OA, especially among Asians. Larger studies with more diverse ethnic populations are needed to confirm these results.
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spelling pubmed-59990642018-06-22 Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population Chen, Jie Wu, Yu Yu, Jiannong Shen, Jinming Braz J Med Biol Res Research Articles Osteoarthritis (OA) is the most common degenerative disease affecting articular cartilage. Some studies indicate that tumor necrosis factor alpha (TNF-α) gene rs1800629 polymorphism was associated with OA risk among Caucasian populations. To examine the role of this candidate gene in Asian populations, we conducted a hospital-based case-control study involving 257 knee OA patients and 305 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan(™) kit. Our study indicated that the AA genotype of TNF-α rs1800629 polymorphism was associated with increased risk of OA. Subsequently, we conducted a meta-analysis and found that rs1800629 polymorphism increased the risk of OA in the recessive and homozygous models. Stratification analysis of ethnicity also obtained a significant association among Asian populations. In conclusion, TNF-α rs1800629 polymorphism confers susceptibility to OA, especially among Asians. Larger studies with more diverse ethnic populations are needed to confirm these results. Associação Brasileira de Divulgação Científica 2018-05-28 /pmc/articles/PMC5999064/ /pubmed/29846433 http://dx.doi.org/10.1590/1414-431X20187311 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Chen, Jie
Wu, Yu
Yu, Jiannong
Shen, Jinming
Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
title Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
title_full Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
title_fullStr Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
title_full_unstemmed Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
title_short Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
title_sort association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a chinese population
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999064/
https://www.ncbi.nlm.nih.gov/pubmed/29846433
http://dx.doi.org/10.1590/1414-431X20187311
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