Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation

Birt-Hogg-Dube’ Syndrome (BHDS) is a rare genetic disorder in humans characterized by skin hamartomas, lung cysts, pneumothorax, and increased risk of renal tumors. BHDS is caused by mutations in the BHD gene, which encodes for Folliculin, a cytoplasmic adapter protein that binds to Folliculin inter...

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Detalles Bibliográficos
Autores principales: Centini, Ryan, Tsang, Mark, Iwata, Terri, Park, Heon, Delrow, Jeffrey, Margineantu, Daciana, Iritani, Brandon M., Gu, Haiwei, Liggitt, H. Denny, Kang, Janella, Kang, Lim, Hockenbery, David M., Raftery, Daniel, Iritani, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999084/
https://www.ncbi.nlm.nih.gov/pubmed/29897930
http://dx.doi.org/10.1371/journal.pone.0197973

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