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Extrapolation of a Brivaracetam Exposure–Response Model from Adults to Children with Focal Seizures

INTRODUCTION: Prediction of brivaracetam effects in children was obtained by scaling an existing adult pharmacokinetic/pharmacodynamic (PK/PD) model for brivaracetam to children, using an existing population PK model for brivaracetam in children. The scaling was supported by estimating the change fr...

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Detalles Bibliográficos
Autores principales:	Schoemaker, Rik, Wade, Janet R., Stockis, Armel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2017
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999174/ https://www.ncbi.nlm.nih.gov/pubmed/28884437 http://dx.doi.org/10.1007/s40262-017-0597-2

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