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Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/N...

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Autores principales: Pałasz, Artur, Pałka, Marcelina, Filipczyk, Łukasz, Menezes, Itiana Castro, Rojczyk, Ewa, Worthington, John J., Piwowarczyk-Nowak, Aneta, Krzystanek, Marek, Wiaderkiewicz, Ryszard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999179/
https://www.ncbi.nlm.nih.gov/pubmed/29488100
http://dx.doi.org/10.1007/s00702-018-1868-2
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author Pałasz, Artur
Pałka, Marcelina
Filipczyk, Łukasz
Menezes, Itiana Castro
Rojczyk, Ewa
Worthington, John J.
Piwowarczyk-Nowak, Aneta
Krzystanek, Marek
Wiaderkiewicz, Ryszard
author_facet Pałasz, Artur
Pałka, Marcelina
Filipczyk, Łukasz
Menezes, Itiana Castro
Rojczyk, Ewa
Worthington, John J.
Piwowarczyk-Nowak, Aneta
Krzystanek, Marek
Wiaderkiewicz, Ryszard
author_sort Pałasz, Artur
collection PubMed
description Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantification via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating effects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses.
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spelling pubmed-59991792018-06-28 Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala Pałasz, Artur Pałka, Marcelina Filipczyk, Łukasz Menezes, Itiana Castro Rojczyk, Ewa Worthington, John J. Piwowarczyk-Nowak, Aneta Krzystanek, Marek Wiaderkiewicz, Ryszard J Neural Transm (Vienna) Psychiatry and Preclinical Psychiatric Studies - Short communication Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantification via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating effects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses. Springer Vienna 2018-02-27 2018 /pmc/articles/PMC5999179/ /pubmed/29488100 http://dx.doi.org/10.1007/s00702-018-1868-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Psychiatry and Preclinical Psychiatric Studies - Short communication
Pałasz, Artur
Pałka, Marcelina
Filipczyk, Łukasz
Menezes, Itiana Castro
Rojczyk, Ewa
Worthington, John J.
Piwowarczyk-Nowak, Aneta
Krzystanek, Marek
Wiaderkiewicz, Ryszard
Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala
title Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala
title_full Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala
title_fullStr Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala
title_full_unstemmed Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala
title_short Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala
title_sort effect of long-term treatment with classical neuroleptics on npq/spexin, kisspeptin and pomc mrna expression in the male rat amygdala
topic Psychiatry and Preclinical Psychiatric Studies - Short communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999179/
https://www.ncbi.nlm.nih.gov/pubmed/29488100
http://dx.doi.org/10.1007/s00702-018-1868-2
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