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Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala
Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/N...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Vienna
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999179/ https://www.ncbi.nlm.nih.gov/pubmed/29488100 http://dx.doi.org/10.1007/s00702-018-1868-2 |
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author | Pałasz, Artur Pałka, Marcelina Filipczyk, Łukasz Menezes, Itiana Castro Rojczyk, Ewa Worthington, John J. Piwowarczyk-Nowak, Aneta Krzystanek, Marek Wiaderkiewicz, Ryszard |
author_facet | Pałasz, Artur Pałka, Marcelina Filipczyk, Łukasz Menezes, Itiana Castro Rojczyk, Ewa Worthington, John J. Piwowarczyk-Nowak, Aneta Krzystanek, Marek Wiaderkiewicz, Ryszard |
author_sort | Pałasz, Artur |
collection | PubMed |
description | Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantification via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating effects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses. |
format | Online Article Text |
id | pubmed-5999179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-59991792018-06-28 Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala Pałasz, Artur Pałka, Marcelina Filipczyk, Łukasz Menezes, Itiana Castro Rojczyk, Ewa Worthington, John J. Piwowarczyk-Nowak, Aneta Krzystanek, Marek Wiaderkiewicz, Ryszard J Neural Transm (Vienna) Psychiatry and Preclinical Psychiatric Studies - Short communication Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantification via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating effects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses. Springer Vienna 2018-02-27 2018 /pmc/articles/PMC5999179/ /pubmed/29488100 http://dx.doi.org/10.1007/s00702-018-1868-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Psychiatry and Preclinical Psychiatric Studies - Short communication Pałasz, Artur Pałka, Marcelina Filipczyk, Łukasz Menezes, Itiana Castro Rojczyk, Ewa Worthington, John J. Piwowarczyk-Nowak, Aneta Krzystanek, Marek Wiaderkiewicz, Ryszard Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala |
title | Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala |
title_full | Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala |
title_fullStr | Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala |
title_full_unstemmed | Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala |
title_short | Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala |
title_sort | effect of long-term treatment with classical neuroleptics on npq/spexin, kisspeptin and pomc mrna expression in the male rat amygdala |
topic | Psychiatry and Preclinical Psychiatric Studies - Short communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999179/ https://www.ncbi.nlm.nih.gov/pubmed/29488100 http://dx.doi.org/10.1007/s00702-018-1868-2 |
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