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Increasing preoperative body size in breast cancer patients between 2002 and 2016: implications for prognosis
Overweight and obesity are increasing worldwide, but the extent in breast cancer patients is unknown. The two aims were to study secular trends in preoperative body mass index (BMI), waist circumference, and breast volume and their impacts on clinical outcome. BMI, waist circumference, and breast vo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999186/ https://www.ncbi.nlm.nih.gov/pubmed/29804217 http://dx.doi.org/10.1007/s10552-018-1042-z |
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author | Wisse, Agatha Tryggvadottir, Helga Simonsson, Maria Isaksson, Karolin Rose, Carsten Ingvar, Christian Jernström, Helena |
author_facet | Wisse, Agatha Tryggvadottir, Helga Simonsson, Maria Isaksson, Karolin Rose, Carsten Ingvar, Christian Jernström, Helena |
author_sort | Wisse, Agatha |
collection | PubMed |
description | Overweight and obesity are increasing worldwide, but the extent in breast cancer patients is unknown. The two aims were to study secular trends in preoperative body mass index (BMI), waist circumference, and breast volume and their impacts on clinical outcome. BMI, waist circumference, and breast volume were measured preoperatively in 24–99-year-old primary breast cancer patients (n = 640) in Sweden 2002–2016. The measurements were analyzed alone and combined in relation to recurrence and overall survival (OS). BMI, waist circumference, and breast volume increased 2002–2016 (p(trends) < 0.0001). Of these, a breast volume ≥ 850 mL was associated with the strongest recurrence-risk (adjusted hazard ratio [(adj)HR] 1.67; 95% CI 1.17–2.39), especially combined with waist circumference ≥ 80 cm ((adj)HR 2.07; 95% CI 1.25–3.44), while BMI ≥ 25 kg/m(2) or large waist circumference conferred almost a twofold risk for death (both Log-Rank p ≤ 0.0001). Chemotherapy seemed to counteract the negative impact of a high BMI or large waist circumference on OS. Large breast volume was the strongest predictor for recurrence in all treatment groups. In conclusion, preoperative BMI, waist circumference, and breast volume increased between 2002 and 2016. Larger body size negatively impacted breast cancer-free interval and OS. If confirmed, body measurements may help select patients requiring more individualized treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10552-018-1042-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5999186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-59991862018-06-28 Increasing preoperative body size in breast cancer patients between 2002 and 2016: implications for prognosis Wisse, Agatha Tryggvadottir, Helga Simonsson, Maria Isaksson, Karolin Rose, Carsten Ingvar, Christian Jernström, Helena Cancer Causes Control Original Paper Overweight and obesity are increasing worldwide, but the extent in breast cancer patients is unknown. The two aims were to study secular trends in preoperative body mass index (BMI), waist circumference, and breast volume and their impacts on clinical outcome. BMI, waist circumference, and breast volume were measured preoperatively in 24–99-year-old primary breast cancer patients (n = 640) in Sweden 2002–2016. The measurements were analyzed alone and combined in relation to recurrence and overall survival (OS). BMI, waist circumference, and breast volume increased 2002–2016 (p(trends) < 0.0001). Of these, a breast volume ≥ 850 mL was associated with the strongest recurrence-risk (adjusted hazard ratio [(adj)HR] 1.67; 95% CI 1.17–2.39), especially combined with waist circumference ≥ 80 cm ((adj)HR 2.07; 95% CI 1.25–3.44), while BMI ≥ 25 kg/m(2) or large waist circumference conferred almost a twofold risk for death (both Log-Rank p ≤ 0.0001). Chemotherapy seemed to counteract the negative impact of a high BMI or large waist circumference on OS. Large breast volume was the strongest predictor for recurrence in all treatment groups. In conclusion, preoperative BMI, waist circumference, and breast volume increased between 2002 and 2016. Larger body size negatively impacted breast cancer-free interval and OS. If confirmed, body measurements may help select patients requiring more individualized treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10552-018-1042-z) contains supplementary material, which is available to authorized users. Springer International Publishing 2018-05-26 2018 /pmc/articles/PMC5999186/ /pubmed/29804217 http://dx.doi.org/10.1007/s10552-018-1042-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Paper Wisse, Agatha Tryggvadottir, Helga Simonsson, Maria Isaksson, Karolin Rose, Carsten Ingvar, Christian Jernström, Helena Increasing preoperative body size in breast cancer patients between 2002 and 2016: implications for prognosis |
title | Increasing preoperative body size in breast cancer patients between 2002 and 2016: implications for prognosis |
title_full | Increasing preoperative body size in breast cancer patients between 2002 and 2016: implications for prognosis |
title_fullStr | Increasing preoperative body size in breast cancer patients between 2002 and 2016: implications for prognosis |
title_full_unstemmed | Increasing preoperative body size in breast cancer patients between 2002 and 2016: implications for prognosis |
title_short | Increasing preoperative body size in breast cancer patients between 2002 and 2016: implications for prognosis |
title_sort | increasing preoperative body size in breast cancer patients between 2002 and 2016: implications for prognosis |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999186/ https://www.ncbi.nlm.nih.gov/pubmed/29804217 http://dx.doi.org/10.1007/s10552-018-1042-z |
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