Oxidative and endoplasmic reticulum stress in respiratory disease

Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of...

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Detalles Bibliográficos
Autores principales: Chen, Alice C‐H, Burr, Lucy, McGuckin, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Special Feature Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999202/
https://www.ncbi.nlm.nih.gov/pubmed/29928501
http://dx.doi.org/10.1002/cti2.1019
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author Chen, Alice C‐H
Burr, Lucy
McGuckin, Michael A
author_facet Chen, Alice C‐H
Burr, Lucy
McGuckin, Michael A
author_sort Chen, Alice C‐H
collection PubMed
description Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.
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spelling pubmed-59992022018-06-20 Oxidative and endoplasmic reticulum stress in respiratory disease Chen, Alice C‐H Burr, Lucy McGuckin, Michael A Clin Transl Immunology Special Feature Reviews Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease. John Wiley and Sons Inc. 2018-06-13 /pmc/articles/PMC5999202/ /pubmed/29928501 http://dx.doi.org/10.1002/cti2.1019 Text en © 2018 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australasian Society for Immunology Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Feature Reviews
Chen, Alice C‐H
Burr, Lucy
McGuckin, Michael A
Oxidative and endoplasmic reticulum stress in respiratory disease
title Oxidative and endoplasmic reticulum stress in respiratory disease
title_full Oxidative and endoplasmic reticulum stress in respiratory disease
title_fullStr Oxidative and endoplasmic reticulum stress in respiratory disease
title_full_unstemmed Oxidative and endoplasmic reticulum stress in respiratory disease
title_short Oxidative and endoplasmic reticulum stress in respiratory disease
title_sort oxidative and endoplasmic reticulum stress in respiratory disease
topic Special Feature Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999202/
https://www.ncbi.nlm.nih.gov/pubmed/29928501
http://dx.doi.org/10.1002/cti2.1019
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