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Accounting for tumor heterogeneity when using CRISPR-Cas9 for cancer progression and drug sensitivity studies
Gene editing protocols often require the use of a subcloning step to isolate successfully edited cells, the behavior of which is then compared to the aggregate parental population and/or other non-edited subclones. Here we demonstrate that the inherent functional heterogeneity present in many cell l...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999218/ https://www.ncbi.nlm.nih.gov/pubmed/29897959 http://dx.doi.org/10.1371/journal.pone.0198790 |