Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1

The splicing factor SRSF1 promotes nonsense-mediated mRNA decay (NMD), a quality control mechanism that degrades mRNAs with premature termination codons (PTCs). Here we show that transcript-bound SRSF1 increases the binding of NMD factor UPF1 to mRNAs while in, or associated with, the nucleus, bypas...

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Detalles Bibliográficos
Autores principales: Aznarez, Isabel, Nomakuchi, Tomoki T., Tetenbaum-Novatt, Jaclyn, Rahman, Mohammad Alinoor, Fregoso, Oliver, Rees, Holly, Krainer, Adrian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999336/
https://www.ncbi.nlm.nih.gov/pubmed/29768215
http://dx.doi.org/10.1016/j.celrep.2018.04.039

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