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Challenges and opportunities for large-scale electrophysiology with Neuropixels probes

Electrophysiological methods are the gold standard in neuroscience because they reveal the activity of individual neurons at high temporal resolution and in arbitrary brain locations. Microelectrode arrays based on complementary metal-oxide semiconductor (CMOS) technology, such as Neuropixels probes...

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Detalles Bibliográficos
Autores principales: Steinmetz, Nicholas A, Koch, Christof, Harris, Kenneth D, Carandini, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999351/
https://www.ncbi.nlm.nih.gov/pubmed/29444488
http://dx.doi.org/10.1016/j.conb.2018.01.009
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author Steinmetz, Nicholas A
Koch, Christof
Harris, Kenneth D
Carandini, Matteo
author_facet Steinmetz, Nicholas A
Koch, Christof
Harris, Kenneth D
Carandini, Matteo
author_sort Steinmetz, Nicholas A
collection PubMed
description Electrophysiological methods are the gold standard in neuroscience because they reveal the activity of individual neurons at high temporal resolution and in arbitrary brain locations. Microelectrode arrays based on complementary metal-oxide semiconductor (CMOS) technology, such as Neuropixels probes, look set to transform these methods. Neuropixels probes provide ∼1000 recording sites on an extremely narrow shank, with on-board amplification, digitization, and multiplexing. They deliver low-noise recordings from hundreds of neurons, providing a step change in the type of data available to neuroscientists. Here we discuss the opportunities afforded by these probes for large-scale electrophysiology, the challenges associated with data processing and anatomical localization, and avenues for further improvements of the technology.
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spelling pubmed-59993512018-06-14 Challenges and opportunities for large-scale electrophysiology with Neuropixels probes Steinmetz, Nicholas A Koch, Christof Harris, Kenneth D Carandini, Matteo Curr Opin Neurobiol Article Electrophysiological methods are the gold standard in neuroscience because they reveal the activity of individual neurons at high temporal resolution and in arbitrary brain locations. Microelectrode arrays based on complementary metal-oxide semiconductor (CMOS) technology, such as Neuropixels probes, look set to transform these methods. Neuropixels probes provide ∼1000 recording sites on an extremely narrow shank, with on-board amplification, digitization, and multiplexing. They deliver low-noise recordings from hundreds of neurons, providing a step change in the type of data available to neuroscientists. Here we discuss the opportunities afforded by these probes for large-scale electrophysiology, the challenges associated with data processing and anatomical localization, and avenues for further improvements of the technology. Current Biology 2018-06 /pmc/articles/PMC5999351/ /pubmed/29444488 http://dx.doi.org/10.1016/j.conb.2018.01.009 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Steinmetz, Nicholas A
Koch, Christof
Harris, Kenneth D
Carandini, Matteo
Challenges and opportunities for large-scale electrophysiology with Neuropixels probes
title Challenges and opportunities for large-scale electrophysiology with Neuropixels probes
title_full Challenges and opportunities for large-scale electrophysiology with Neuropixels probes
title_fullStr Challenges and opportunities for large-scale electrophysiology with Neuropixels probes
title_full_unstemmed Challenges and opportunities for large-scale electrophysiology with Neuropixels probes
title_short Challenges and opportunities for large-scale electrophysiology with Neuropixels probes
title_sort challenges and opportunities for large-scale electrophysiology with neuropixels probes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999351/
https://www.ncbi.nlm.nih.gov/pubmed/29444488
http://dx.doi.org/10.1016/j.conb.2018.01.009
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