Loss-of-function mutation in Hippo suppressed enlargement of lysosomes and neurodegeneration caused by dFIG4 knockdown

Charcot–Marie–Tooth disease (CMT) is the most common hereditary neuropathy, and more than 80 CMT-causing genes have been identified to date. CMT4J is caused by a loss-of-function mutation in the Factor-Induced-Gene 4 (FIG4) gene, the product of which plays important roles in endosome–lysosome homeos...

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Detalles Bibliográficos
Autores principales: Kushimura, Yukie, Azuma, Yumiko, Mizuta, Ikuko, Muraoka, Yuuka, Kyotani, Akane, Yoshida, Hideki, Tokuda, Takahiko, Mizuno, Toshiki, Yamaguchi, Masamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Degeneration and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999369/
https://www.ncbi.nlm.nih.gov/pubmed/29742619
http://dx.doi.org/10.1097/WNR.0000000000001044

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