Glutathione-mimetic D609 alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model

Excessive extracellular deposition of amyloid-β-peptide (Aβ) in the brain is a pathological hallmark of Alzheimer’s disease (AD). Oxidative stress is associated with the onset and progression of AD and contributes to Aβ generation. Tricyclodecan-9-yl-xanthogenate (D609) is a glutathione (GSH)-mimeti...

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Detalles Bibliográficos
Autores principales: Yang, Hui, Xie, ZhaoHong, Wei, LiFei, Ding, Mao, Wang, Ping, Bi, JianZhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Cellular, Molecular and Developmental Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999370/
https://www.ncbi.nlm.nih.gov/pubmed/29672445
http://dx.doi.org/10.1097/WNR.0000000000001040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999370/
https://www.ncbi.nlm.nih.gov/pubmed/29672445
http://dx.doi.org/10.1097/WNR.0000000000001040

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