The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

The HIV-1 Tat protein hijacks P-TEFb kinase to activate paused RNA polymerase II (RNAP II) at the viral promoter. Tat binds additional host factors, but it is unclear how they regulate RNAP II elongation. Here, we identify the cytoplasmic ubiquitin ligase UBE2O as critical for Tat transcriptional ac...

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Detalles Bibliográficos
Autores principales: Faust, Tyler B, Li, Yang, Bacon, Curtis W, Jang, Gwendolyn M, Weiss, Amit, Jayaraman, Bhargavi, Newton, Billy W, Krogan, Nevan J, D'Orso, Iván, Frankel, Alan D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999396/
https://www.ncbi.nlm.nih.gov/pubmed/29845934
http://dx.doi.org/10.7554/eLife.31879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999396/
https://www.ncbi.nlm.nih.gov/pubmed/29845934
http://dx.doi.org/10.7554/eLife.31879

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