Cargando…
Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging
RATIONALE: Pleomorphic adenoma, the most common tumor of the salivary glands, is usually benign. It is well known, however, that pleomorphic adenomas occasionally undergo malignant transformation to carcinoma ex pleomorphic adenoma and can metastasize. More rarely pleomorphic adenomas can metastasiz...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999481/ https://www.ncbi.nlm.nih.gov/pubmed/29879077 http://dx.doi.org/10.1097/MD.0000000000011077 |
_version_ | 1783331434222583808 |
---|---|
author | Koyama, Masamichi Terauchi, Takashi Koizumi, Mitsuru Tanaka, Hiroko Sato, Yukiko |
author_facet | Koyama, Masamichi Terauchi, Takashi Koizumi, Mitsuru Tanaka, Hiroko Sato, Yukiko |
author_sort | Koyama, Masamichi |
collection | PubMed |
description | RATIONALE: Pleomorphic adenoma, the most common tumor of the salivary glands, is usually benign. It is well known, however, that pleomorphic adenomas occasionally undergo malignant transformation to carcinoma ex pleomorphic adenoma and can metastasize. More rarely pleomorphic adenomas can metastasize without histological malignant transformation. We herein report an unusual case of pleomorphic adenoma with multiple metastases comprehensively demonstrated on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). PATIENT CONCERNS: A 63-year-old woman was referred to our hospital because of urine occult blood and lung nodules detected on a health checkup. She had a history of resection of a pleomorphic adenoma in the parotid gland at the age of 40 years and tumor recurrence at the age of 53 years. CT scan and magnetic resonance imaging revealed bilateral renal tumors, multiple pulmonary nodules, and an osteolytic lesion in the first lumbar vertebra. DIAGNOSES: Ultrasonography-guided percutaneous biopsy of the right renal tumor revealed a myxoid epithelial tumor that was consistent with metastasis of the pleomorphic adenoma from the parotid gland. INTERVENTIONS: The patient was carefully observed with regular imaging examinations. OUTCOMES: The multiple lesions gradually progressed, and FDG-PET/CT subsequently revealed additional metastases in the liver and perineum. LESSONS: Metastases of pleomorphic adenomas may occur years after the initial disease in association with local recurrences. Careful observation with whole-body imaging such as FDG-PET/CT is necessary. |
format | Online Article Text |
id | pubmed-5999481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-59994812018-06-20 Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging Koyama, Masamichi Terauchi, Takashi Koizumi, Mitsuru Tanaka, Hiroko Sato, Yukiko Medicine (Baltimore) Research Article RATIONALE: Pleomorphic adenoma, the most common tumor of the salivary glands, is usually benign. It is well known, however, that pleomorphic adenomas occasionally undergo malignant transformation to carcinoma ex pleomorphic adenoma and can metastasize. More rarely pleomorphic adenomas can metastasize without histological malignant transformation. We herein report an unusual case of pleomorphic adenoma with multiple metastases comprehensively demonstrated on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). PATIENT CONCERNS: A 63-year-old woman was referred to our hospital because of urine occult blood and lung nodules detected on a health checkup. She had a history of resection of a pleomorphic adenoma in the parotid gland at the age of 40 years and tumor recurrence at the age of 53 years. CT scan and magnetic resonance imaging revealed bilateral renal tumors, multiple pulmonary nodules, and an osteolytic lesion in the first lumbar vertebra. DIAGNOSES: Ultrasonography-guided percutaneous biopsy of the right renal tumor revealed a myxoid epithelial tumor that was consistent with metastasis of the pleomorphic adenoma from the parotid gland. INTERVENTIONS: The patient was carefully observed with regular imaging examinations. OUTCOMES: The multiple lesions gradually progressed, and FDG-PET/CT subsequently revealed additional metastases in the liver and perineum. LESSONS: Metastases of pleomorphic adenomas may occur years after the initial disease in association with local recurrences. Careful observation with whole-body imaging such as FDG-PET/CT is necessary. Wolters Kluwer Health 2018-06-18 /pmc/articles/PMC5999481/ /pubmed/29879077 http://dx.doi.org/10.1097/MD.0000000000011077 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Koyama, Masamichi Terauchi, Takashi Koizumi, Mitsuru Tanaka, Hiroko Sato, Yukiko Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging |
title | Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging |
title_full | Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging |
title_fullStr | Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging |
title_full_unstemmed | Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging |
title_short | Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging |
title_sort | metastasizing pleomorphic adenoma in the multiple organs: a case report on fdg-pet/ct imaging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999481/ https://www.ncbi.nlm.nih.gov/pubmed/29879077 http://dx.doi.org/10.1097/MD.0000000000011077 |
work_keys_str_mv | AT koyamamasamichi metastasizingpleomorphicadenomainthemultipleorgansacasereportonfdgpetctimaging AT terauchitakashi metastasizingpleomorphicadenomainthemultipleorgansacasereportonfdgpetctimaging AT koizumimitsuru metastasizingpleomorphicadenomainthemultipleorgansacasereportonfdgpetctimaging AT tanakahiroko metastasizingpleomorphicadenomainthemultipleorgansacasereportonfdgpetctimaging AT satoyukiko metastasizingpleomorphicadenomainthemultipleorgansacasereportonfdgpetctimaging |