肺移植术后肺癌1例报告并文献复习

BACKGROUND AND OBJECTIVE: Lung transplantation is an efcient therapeutic option for patients with end-stage pulmonary diseases, but less is known about lung cancer afer lung transplantation. The aim of this study is to improve the awareness, diagnosis and treatment of bronchogenic carcinoma after lung transplantation with a case report and related literatures. METHODS: We reported a 65-year-old male with idiopathic pulmonary fbrosis (IPF) who underwent right lung transplantation under extracorporeal membrane oxygenation (ECMO) support in May 2007 in our hospital. The patient recovered smoothly and discharged from the hospital 46 days afer the procedure with regular follow-up. Immunosuppression therapy was triple drug maintenance regimen including tacrolimus (Tac), mycophenolate mofetil (MMF) and steroids. RESULTS: Small cell lung cancer in the lef lung with multiple osseous metastases was found 13 months afer the lung transplantation. Symptoms were relieved a bit by administering chemotherapeutics (etoposide and cisplatin) for 4 cycles. However, the patient was succumbed to his illness within 11 months afer the diagnosis of lung cancer. CONCLUSION: Lung cancer afer lung transplantation has been suggested as one of causes of late mortality with the risk factors such as chronic obstructive pulmonary disease (COPD), IPF, cigarete smoking history and immunosuppression etc. Early diagnosis and treatment are very important to improve the prognosis.