工作环境烟草暴露与肺癌发生危险的系统评价

BACKGROUND AND OBJECTIVE: It has been reported that there was a close relationship between lung cancer risk and environmental tobacco smoke at workplace. The aim of this study is to explore the relationship between workplace environmental tobacco smoke exposure and lung cancer risk among non-smoking subjects. METHODS: By searching Medline, CENTRL (the Cochrane central register of controlledtrials), EMBASE, CBM, CNKI and VIP et al, we collected both domestic and overseas published documents on workplace environmental tobacco smoke exposure and lung cancer risk. Random or fxed effect models were applied to conduct systematic review on the study results, the combined odds ratio (OR) and the 95% confdence interval (CI) were calculated as well. RESULTS: 22 reports were included into the combined analysis, which indicated that 25% lung cancer risk was increased by exposing to workplace environment tobacco smoke (OR=1.25, 95%CI: 1.13-1.39, P < 0.001). For female the increased risk was 22% (OR=1.22, 95%CI: 1.05-1.42, P=0.011). For male the increased risk was 54%, but it does not reach the statistical signifcance (OR=1.54, 95%CI: 0.74-3.18, P=0.247). CONCLUSION: Workplace environmental tobacco smoke exposure is an important risk factor of lung cancer risk among non-smoking subjects. Especially for non-smoking women who expose to workplace environment tobacco smoke have a close relationship with lung cancer.