Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β(+) T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3(+) T Cells and Immunoregulatory Molecules

In recent years, immunotherapy has shown considerable promise in the management of several malignancies. However, the majority of preclinical studies have been conducted in rodents, the results of which often translate poorly to patients given the substantial differences between murine and human imm...

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Detalles Bibliográficos
Autores principales: Overgaard, Nana H., Principe, Daniel R., Schachtschneider, Kyle M., Jakobsen, Jeanne Toft, Rund, Laurie A., Grippo, Paul J., Schook, Lawrence B., Jungersen, Gregers
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999797/
https://www.ncbi.nlm.nih.gov/pubmed/29930558
http://dx.doi.org/10.3389/fimmu.2018.01301

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