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培美曲塞在晚期非小细胞肺癌二线及以上治疗中的疗效分析
BACKGROUND AND OBJECTIVE: Pemetrexed is a standard second-line therapy in advanced non-small cell lung cancer (NSCLC). Currently, cytotoxic treatments beyond second-line therapy are not available. This study evaluated the efficacy and safety of pemetrexed as a salvage regimen in heavily pretreated p...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
Publicado: |
中国肺癌杂志编辑部
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999869/ https://www.ncbi.nlm.nih.gov/pubmed/22429582 http://dx.doi.org/10.3779/j.issn.1009-3419.2012.03.08 |
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collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Pemetrexed is a standard second-line therapy in advanced non-small cell lung cancer (NSCLC). Currently, cytotoxic treatments beyond second-line therapy are not available. This study evaluated the efficacy and safety of pemetrexed as a salvage regimen in heavily pretreated patients with NSCLC. METHODS: Clinical data on 37 patients with advanced NSCLC who received pemetrexed as second-line therapy or beyond in Cancer Hospital of Peking Union Medical College from Feb 2005 to Sep 2009 were reviewed and analyzed retrospectively. RESULTS: Thirteen patients (35.1%) received pemetrexed as second-line treatment, whereas 24 (64.9%) received it as third-line treatment or beyond. Complete response, partial response, stable disease and progressive disease were noted in 1 (2.7%), 2 (5.4%), 17 (45.9%) and 12 (32.4%) of the patients, respectively, with the disease control rate being 54.1%. The median duration of progression free survival was 8.05 months, whereas that of overall survival was 19.29 months. CONCLUSION: Pemetrexed is efficacious and tolerable as second-line therapy or beyond for advanced NSCLC and should thus be recommended for patients with this disease. |
format | Online Article Text |
id | pubmed-5999869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | 中国肺癌杂志编辑部 |
record_format | MEDLINE/PubMed |
spelling | pubmed-59998692018-07-06 培美曲塞在晚期非小细胞肺癌二线及以上治疗中的疗效分析 Zhongguo Fei Ai Za Zhi 临床经验 BACKGROUND AND OBJECTIVE: Pemetrexed is a standard second-line therapy in advanced non-small cell lung cancer (NSCLC). Currently, cytotoxic treatments beyond second-line therapy are not available. This study evaluated the efficacy and safety of pemetrexed as a salvage regimen in heavily pretreated patients with NSCLC. METHODS: Clinical data on 37 patients with advanced NSCLC who received pemetrexed as second-line therapy or beyond in Cancer Hospital of Peking Union Medical College from Feb 2005 to Sep 2009 were reviewed and analyzed retrospectively. RESULTS: Thirteen patients (35.1%) received pemetrexed as second-line treatment, whereas 24 (64.9%) received it as third-line treatment or beyond. Complete response, partial response, stable disease and progressive disease were noted in 1 (2.7%), 2 (5.4%), 17 (45.9%) and 12 (32.4%) of the patients, respectively, with the disease control rate being 54.1%. The median duration of progression free survival was 8.05 months, whereas that of overall survival was 19.29 months. CONCLUSION: Pemetrexed is efficacious and tolerable as second-line therapy or beyond for advanced NSCLC and should thus be recommended for patients with this disease. 中国肺癌杂志编辑部 2012-03-20 /pmc/articles/PMC5999869/ /pubmed/22429582 http://dx.doi.org/10.3779/j.issn.1009-3419.2012.03.08 Text en 版权所有©《中国肺癌杂志》编辑部2012 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | 临床经验 培美曲塞在晚期非小细胞肺癌二线及以上治疗中的疗效分析 |
title | 培美曲塞在晚期非小细胞肺癌二线及以上治疗中的疗效分析 |
title_full | 培美曲塞在晚期非小细胞肺癌二线及以上治疗中的疗效分析 |
title_fullStr | 培美曲塞在晚期非小细胞肺癌二线及以上治疗中的疗效分析 |
title_full_unstemmed | 培美曲塞在晚期非小细胞肺癌二线及以上治疗中的疗效分析 |
title_short | 培美曲塞在晚期非小细胞肺癌二线及以上治疗中的疗效分析 |
title_sort | 培美曲塞在晚期非小细胞肺癌二线及以上治疗中的疗效分析 |
topic | 临床经验 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999869/ https://www.ncbi.nlm.nih.gov/pubmed/22429582 http://dx.doi.org/10.3779/j.issn.1009-3419.2012.03.08 |
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