Langerhans cell histiocytosis of bone in an adult: A case report

Langerhans cell histiocytosis (LCH) may clinically manifest in a variety of ways due to its ability to involve nearly every organ system. LCH may present as a single bone lesion, skin rash, or as invasive disseminated disease and occurs typically in the pediatric and adolescent population, affecting...

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Detalles Bibliográficos
Autores principales: Christopher, Zachary, Binitie, Odion, Henderson-Jackson, Evita, Perno, Joseph, Makanji, Rikesh J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Musculoskeletal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999879/
https://www.ncbi.nlm.nih.gov/pubmed/29904462
http://dx.doi.org/10.1016/j.radcr.2017.11.020
Descripción
Sumario:Langerhans cell histiocytosis (LCH) may clinically manifest in a variety of ways due to its ability to involve nearly every organ system. LCH may present as a single bone lesion, skin rash, or as invasive disseminated disease and occurs typically in the pediatric and adolescent population, affecting both males and females. Independent of its clinical presentation and severity, LCH lesions share the common histology of CD1a(+)/CD207(+) dendritic cells along with an inflammatory infiltrate, and, based upon improved scientific understanding, is now classified as a myeloproliferative neoplasm. We present a case report of an adult diagnosed with LCH of the pelvis.

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