非小细胞肺癌治疗的新靶点：EML4-ALK融合基因

It was only 3 years ago that the fusion gene between echinoderm microtubule-associated protein-like4 (EML4) and anaplastic lymphoma kinase (ALK) has been identified in a subset of non-small cell lung cancer (NSCLC). EML4-ALK is most often detected in never smokers with lung adenocarcinoma and has un...

Descripción completa

Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2011
Materias:
综述
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999890/
https://www.ncbi.nlm.nih.gov/pubmed/21645460
http://dx.doi.org/10.3779/j.issn.1009-3419.2011.06.11
_version_ 1783331544526487552
collection PubMed
description It was only 3 years ago that the fusion gene between echinoderm microtubule-associated protein-like4 (EML4) and anaplastic lymphoma kinase (ALK) has been identified in a subset of non-small cell lung cancer (NSCLC). EML4-ALK is most often detected in never smokers with lung adenocarcinoma and has unique pathologic features. EML4-ALK fusion gene is oncogenic, which could be suppressed by ALK-inhibitor through blocking the downstream signaling passway of EML4-ALK. This review will focus on the molecular structure, function, biology, detection method and the diagnostic and therapeutic meaning of EML4-ALK of lung cancer.
format Online
Article
Text
id pubmed-5999890
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher 中国肺癌杂志编辑部
record_format MEDLINE/PubMed
spelling pubmed-59998902018-07-06 非小细胞肺癌治疗的新靶点：EML4-ALK融合基因 Zhongguo Fei Ai Za Zhi 综述 It was only 3 years ago that the fusion gene between echinoderm microtubule-associated protein-like4 (EML4) and anaplastic lymphoma kinase (ALK) has been identified in a subset of non-small cell lung cancer (NSCLC). EML4-ALK is most often detected in never smokers with lung adenocarcinoma and has unique pathologic features. EML4-ALK fusion gene is oncogenic, which could be suppressed by ALK-inhibitor through blocking the downstream signaling passway of EML4-ALK. This review will focus on the molecular structure, function, biology, detection method and the diagnostic and therapeutic meaning of EML4-ALK of lung cancer. 中国肺癌杂志编辑部 2011-06-20 /pmc/articles/PMC5999890/ /pubmed/21645460 http://dx.doi.org/10.3779/j.issn.1009-3419.2011.06.11 Text en 版权所有©《中国肺癌杂志》编辑部2011 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/
spellingShingle 综述
非小细胞肺癌治疗的新靶点：EML4-ALK融合基因
title 非小细胞肺癌治疗的新靶点：EML4-ALK融合基因
title_full 非小细胞肺癌治疗的新靶点：EML4-ALK融合基因
title_fullStr 非小细胞肺癌治疗的新靶点：EML4-ALK融合基因
title_full_unstemmed 非小细胞肺癌治疗的新靶点：EML4-ALK融合基因
title_short 非小细胞肺癌治疗的新靶点：EML4-ALK融合基因
title_sort 非小细胞肺癌治疗的新靶点：eml4-alk融合基因
topic 综述
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999890/
https://www.ncbi.nlm.nih.gov/pubmed/21645460
http://dx.doi.org/10.3779/j.issn.1009-3419.2011.06.11
work_keys_str_mv AT fēixiǎoxìbāofèiáizhìliáodexīnbǎdiǎneml4alkrónghéjīyīn

Ejemplares similares