Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia

The DosR regulon is believed to be a key factor in latency adaptation of Mycobacterium tuberculosis and is strongly induced by multiple stresses, including hypoxia. Previous studies have revealed reversible acetylation of the conserved core DNA-binding lysine residue 182 (K182) of DosR in M. tubercu...

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Detalles Bibliográficos
Autores principales: Bi, Jing, Gou, Zongchao, Zhou, Fengzhu, Chen, Yiqing, Gan, Jianhua, Liu, Jun, Wang, Honghai, Zhang, Xuelian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999986/
https://www.ncbi.nlm.nih.gov/pubmed/29899473
http://dx.doi.org/10.1038/s41426-018-0112-3

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