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A rapid, computational approach for assessing interfraction esophageal motion for use in stereotactic body radiation therapy planning

PURPOSE: We present a rapid computational method for quantifying interfraction motion of the esophagus in patients undergoing stereotactic body radiation therapy on a magnetic resonance (MR) guided radiation therapy system. METHODS AND MATERIALS: Patients who underwent stereotactic body radiation th...

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Detalles Bibliográficos
Autores principales: Cardenas, Michael L., Mazur, Thomas R., Tsien, Christina I., Green, Olga L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000025/
https://www.ncbi.nlm.nih.gov/pubmed/29904747
http://dx.doi.org/10.1016/j.adro.2017.10.003
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author Cardenas, Michael L.
Mazur, Thomas R.
Tsien, Christina I.
Green, Olga L.
author_facet Cardenas, Michael L.
Mazur, Thomas R.
Tsien, Christina I.
Green, Olga L.
author_sort Cardenas, Michael L.
collection PubMed
description PURPOSE: We present a rapid computational method for quantifying interfraction motion of the esophagus in patients undergoing stereotactic body radiation therapy on a magnetic resonance (MR) guided radiation therapy system. METHODS AND MATERIALS: Patients who underwent stereotactic body radiation therapy had simulation computed tomography (CT) and on-treatment MR scans performed. The esophagus was contoured on each scan. CT contours were transferred to MR volumes via rigid registration. Digital Imaging and Communications in Medicine files containing contour points were exported to MATLAB. In-plane CT and MR contour points were spline interpolated, yielding boundaries with centroid positions, C(CT) and C(MR). MR contour points lying outside of the CT contour were extracted. For each such point, B(MR)(j), a segment from C(CT) intersecting B(MR)(j), was produced; its intersection with the CT contour, B(CT)(i), was calculated. The length of the segment S(ij), between B(CT)(i) and B(MR)(j), was found. The orientation θ was calculated from S(ij) vector components: θ = arctan[(S(ij))(y) / (S(ij))(x)] A set of segments {S(ij)} was produced for each slice and binned by quadrant with 0° < θ ≤ 90°, 90° < θ ≤ 180°, 180° < θ ≤ 270°, and 270° < θ ≤ 360° for the left anterior, right anterior, right posterior, and left posterior quadrants, respectively. Slices were binned into upper, middle, and lower esophageal (LE) segments. RESULTS: Seven patients, each having 3 MR scans, were evaluated, yielding 1629 axial slices and 84,716 measurements. The LE segment exhibited the greatest magnitude of motion. The mean LE measurements in the left anterior, left posterior, right anterior, and right posterior were 5.2 ± 0.07 mm, 6.0 ± 0.09 mm, 4.8 ± 0.08 mm, and 5.1 ± 0.08 mm, respectively. There was considerable interpatient variability. CONCLUSIONS: The LE segment exhibited the greatest magnitude of mobility compared with the middle and upper esophageal segments. A novel computational method enables personalized, nonuniform esophageal margins to be tailored to individual patients.
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spelling pubmed-60000252018-06-14 A rapid, computational approach for assessing interfraction esophageal motion for use in stereotactic body radiation therapy planning Cardenas, Michael L. Mazur, Thomas R. Tsien, Christina I. Green, Olga L. Adv Radiat Oncol Treatment Planning PURPOSE: We present a rapid computational method for quantifying interfraction motion of the esophagus in patients undergoing stereotactic body radiation therapy on a magnetic resonance (MR) guided radiation therapy system. METHODS AND MATERIALS: Patients who underwent stereotactic body radiation therapy had simulation computed tomography (CT) and on-treatment MR scans performed. The esophagus was contoured on each scan. CT contours were transferred to MR volumes via rigid registration. Digital Imaging and Communications in Medicine files containing contour points were exported to MATLAB. In-plane CT and MR contour points were spline interpolated, yielding boundaries with centroid positions, C(CT) and C(MR). MR contour points lying outside of the CT contour were extracted. For each such point, B(MR)(j), a segment from C(CT) intersecting B(MR)(j), was produced; its intersection with the CT contour, B(CT)(i), was calculated. The length of the segment S(ij), between B(CT)(i) and B(MR)(j), was found. The orientation θ was calculated from S(ij) vector components: θ = arctan[(S(ij))(y) / (S(ij))(x)] A set of segments {S(ij)} was produced for each slice and binned by quadrant with 0° < θ ≤ 90°, 90° < θ ≤ 180°, 180° < θ ≤ 270°, and 270° < θ ≤ 360° for the left anterior, right anterior, right posterior, and left posterior quadrants, respectively. Slices were binned into upper, middle, and lower esophageal (LE) segments. RESULTS: Seven patients, each having 3 MR scans, were evaluated, yielding 1629 axial slices and 84,716 measurements. The LE segment exhibited the greatest magnitude of motion. The mean LE measurements in the left anterior, left posterior, right anterior, and right posterior were 5.2 ± 0.07 mm, 6.0 ± 0.09 mm, 4.8 ± 0.08 mm, and 5.1 ± 0.08 mm, respectively. There was considerable interpatient variability. CONCLUSIONS: The LE segment exhibited the greatest magnitude of mobility compared with the middle and upper esophageal segments. A novel computational method enables personalized, nonuniform esophageal margins to be tailored to individual patients. Elsevier 2017-10-31 /pmc/articles/PMC6000025/ /pubmed/29904747 http://dx.doi.org/10.1016/j.adro.2017.10.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Treatment Planning
Cardenas, Michael L.
Mazur, Thomas R.
Tsien, Christina I.
Green, Olga L.
A rapid, computational approach for assessing interfraction esophageal motion for use in stereotactic body radiation therapy planning
title A rapid, computational approach for assessing interfraction esophageal motion for use in stereotactic body radiation therapy planning
title_full A rapid, computational approach for assessing interfraction esophageal motion for use in stereotactic body radiation therapy planning
title_fullStr A rapid, computational approach for assessing interfraction esophageal motion for use in stereotactic body radiation therapy planning
title_full_unstemmed A rapid, computational approach for assessing interfraction esophageal motion for use in stereotactic body radiation therapy planning
title_short A rapid, computational approach for assessing interfraction esophageal motion for use in stereotactic body radiation therapy planning
title_sort rapid, computational approach for assessing interfraction esophageal motion for use in stereotactic body radiation therapy planning
topic Treatment Planning
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000025/
https://www.ncbi.nlm.nih.gov/pubmed/29904747
http://dx.doi.org/10.1016/j.adro.2017.10.003
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