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铂类抗肿瘤药物相关肾损伤作用机制的研究进展
Platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors, lung cancer, and colorectal cancer. Two major problems exist, however, in the clinic use of platinum derivatives. One is the development of t...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
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中国肺癌杂志编辑部
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000109/ https://www.ncbi.nlm.nih.gov/pubmed/26383983 http://dx.doi.org/10.3779/j.issn.1009-3419.2015.09.09 |
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collection | PubMed |
description | Platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors, lung cancer, and colorectal cancer. Two major problems exist, however, in the clinic use of platinum derivatives. One is the development of tumor resistance to the drug during therapy, leading to treatment failure. The other is the drug's toxicity such as the cisplatin's nephrotoxicity, which limits the dose that can be administered. This paper describes the mechanism of platinum derivatives induced kidney injury. |
format | Online Article Text |
id | pubmed-6000109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | 中国肺癌杂志编辑部 |
record_format | MEDLINE/PubMed |
spelling | pubmed-60001092018-07-06 铂类抗肿瘤药物相关肾损伤作用机制的研究进展 Zhongguo Fei Ai Za Zhi 综述 Platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors, lung cancer, and colorectal cancer. Two major problems exist, however, in the clinic use of platinum derivatives. One is the development of tumor resistance to the drug during therapy, leading to treatment failure. The other is the drug's toxicity such as the cisplatin's nephrotoxicity, which limits the dose that can be administered. This paper describes the mechanism of platinum derivatives induced kidney injury. 中国肺癌杂志编辑部 2015-09-20 /pmc/articles/PMC6000109/ /pubmed/26383983 http://dx.doi.org/10.3779/j.issn.1009-3419.2015.09.09 Text en 版权所有©《中国肺癌杂志》编辑部2015 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | 综述 铂类抗肿瘤药物相关肾损伤作用机制的研究进展 |
title | 铂类抗肿瘤药物相关肾损伤作用机制的研究进展 |
title_full | 铂类抗肿瘤药物相关肾损伤作用机制的研究进展 |
title_fullStr | 铂类抗肿瘤药物相关肾损伤作用机制的研究进展 |
title_full_unstemmed | 铂类抗肿瘤药物相关肾损伤作用机制的研究进展 |
title_short | 铂类抗肿瘤药物相关肾损伤作用机制的研究进展 |
title_sort | 铂类抗肿瘤药物相关肾损伤作用机制的研究进展 |
topic | 综述 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000109/ https://www.ncbi.nlm.nih.gov/pubmed/26383983 http://dx.doi.org/10.3779/j.issn.1009-3419.2015.09.09 |
work_keys_str_mv | AT bólèikàngzhǒngliúyàowùxiāngguānshènsǔnshāngzuòyòngjīzhìdeyánjiūjìnzhǎn |