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肺癌相关成纤维细胞的研究进展
Cancer-associated fibroblasts (CAFs) is fibroblast cells activated by cancer cells in tumor with myofibroblasts cells (MFs) properties. CAFs is the main components of the tumor microenvironment. Malignant conversion of CAFs phenotype is closely related to the tumor evolution. In this review, we summ...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
中国肺癌杂志编辑部
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000303/ https://www.ncbi.nlm.nih.gov/pubmed/22681927 http://dx.doi.org/10.3779/j.issn.1009-3419.2012.06.11 |
| _version_ | 1783331675518795776 |
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| collection | PubMed |
| description | Cancer-associated fibroblasts (CAFs) is fibroblast cells activated by cancer cells in tumor with myofibroblasts cells (MFs) properties. CAFs is the main components of the tumor microenvironment. Malignant conversion of CAFs phenotype is closely related to the tumor evolution. In this review, we summarized that: (1) The source of CAFs and morphology, and the relation between heterogenicity and the malignant phenotype conversion of CAFs with time-space change; (2) The current research status and question of clinical application on CAFs; (3) The relation of CAFs and invasion and metastasis of lung cancer; (4) CAFs in the prognosis and treatment of lung cancer. |
| format | Online Article Text |
| id | pubmed-6000303 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | 中国肺癌杂志编辑部 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-60003032018-07-06 肺癌相关成纤维细胞的研究进展 Zhongguo Fei Ai Za Zhi 综述 Cancer-associated fibroblasts (CAFs) is fibroblast cells activated by cancer cells in tumor with myofibroblasts cells (MFs) properties. CAFs is the main components of the tumor microenvironment. Malignant conversion of CAFs phenotype is closely related to the tumor evolution. In this review, we summarized that: (1) The source of CAFs and morphology, and the relation between heterogenicity and the malignant phenotype conversion of CAFs with time-space change; (2) The current research status and question of clinical application on CAFs; (3) The relation of CAFs and invasion and metastasis of lung cancer; (4) CAFs in the prognosis and treatment of lung cancer. 中国肺癌杂志编辑部 2012-06-20 /pmc/articles/PMC6000303/ /pubmed/22681927 http://dx.doi.org/10.3779/j.issn.1009-3419.2012.06.11 Text en 版权所有©《中国肺癌杂志》编辑部2012 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/ |
| spellingShingle | 综述 肺癌相关成纤维细胞的研究进展 |
| title | 肺癌相关成纤维细胞的研究进展 |
| title_full | 肺癌相关成纤维细胞的研究进展 |
| title_fullStr | 肺癌相关成纤维细胞的研究进展 |
| title_full_unstemmed | 肺癌相关成纤维细胞的研究进展 |
| title_short | 肺癌相关成纤维细胞的研究进展 |
| title_sort | 肺癌相关成纤维细胞的研究进展 |
| topic | 综述 |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000303/ https://www.ncbi.nlm.nih.gov/pubmed/22681927 http://dx.doi.org/10.3779/j.issn.1009-3419.2012.06.11 |
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