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甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的Meta分析

BACKGROUND AND OBJECTIVE: The efficacy and safety of radiosensitivity on non-small cell lung cancer (NSCLC) using metronidazole amino acidum natrium (CMNa) are yet to be proven. This study evaluates the efficacy and safety of radiosensitivity on NSCLC by CMNa to provide references for further clinic...

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Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000306/
https://www.ncbi.nlm.nih.gov/pubmed/22681920
http://dx.doi.org/10.3779/j.issn.1009-3419.2012.06.04
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description BACKGROUND AND OBJECTIVE: The efficacy and safety of radiosensitivity on non-small cell lung cancer (NSCLC) using metronidazole amino acidum natrium (CMNa) are yet to be proven. This study evaluates the efficacy and safety of radiosensitivity on NSCLC by CMNa to provide references for further clinical practice and research. METHODS: Relevant randomized controlled trials (RCTs) were obtained from the Cochrane library, Pubmed, EMbase, CBM, CNKI, VIP, and Wan Fang databases. Dates were searched through other means. RCTs of radiosensitivity on NSCLC by CMNa were included. The data included in the study were evaluated and analyzed using the Cochrane Collaboration' s RevMan 5.1 software. RESULTS: A total of 21 RCTs were included. The results of the meta-analyses showed that the total effective rate of the test group that received CMNa plus radiotherapy was higher than that of the control group that received radiotherapy alone (OR=3.29, 95%CI: 2.47-4.39, P < 0.000, 01) or radiotherapy plus placebo (OR=3.65, 95%CI: 2.25-5.92, P < 0.000, 01), respectively. No significant differences were found in the quality of life between one and two-year survival rates (P>0.05). No significant differences were found among radiation pneumonitis, radiation esophagitis, hematological toxicity, and cardiotoxicity (P>0.05). CONCLUSION: CMNa plus radiotherapy elicit beneficial effects in the treatment of NSCLC and produce fewer adverse effects. Therefore, this technique can be recommended and applied in clinics.
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spelling pubmed-60003062018-07-06 甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的Meta分析 Zhongguo Fei Ai Za Zhi 临床研究 BACKGROUND AND OBJECTIVE: The efficacy and safety of radiosensitivity on non-small cell lung cancer (NSCLC) using metronidazole amino acidum natrium (CMNa) are yet to be proven. This study evaluates the efficacy and safety of radiosensitivity on NSCLC by CMNa to provide references for further clinical practice and research. METHODS: Relevant randomized controlled trials (RCTs) were obtained from the Cochrane library, Pubmed, EMbase, CBM, CNKI, VIP, and Wan Fang databases. Dates were searched through other means. RCTs of radiosensitivity on NSCLC by CMNa were included. The data included in the study were evaluated and analyzed using the Cochrane Collaboration' s RevMan 5.1 software. RESULTS: A total of 21 RCTs were included. The results of the meta-analyses showed that the total effective rate of the test group that received CMNa plus radiotherapy was higher than that of the control group that received radiotherapy alone (OR=3.29, 95%CI: 2.47-4.39, P < 0.000, 01) or radiotherapy plus placebo (OR=3.65, 95%CI: 2.25-5.92, P < 0.000, 01), respectively. No significant differences were found in the quality of life between one and two-year survival rates (P>0.05). No significant differences were found among radiation pneumonitis, radiation esophagitis, hematological toxicity, and cardiotoxicity (P>0.05). CONCLUSION: CMNa plus radiotherapy elicit beneficial effects in the treatment of NSCLC and produce fewer adverse effects. Therefore, this technique can be recommended and applied in clinics. 中国肺癌杂志编辑部 2012-06-20 /pmc/articles/PMC6000306/ /pubmed/22681920 http://dx.doi.org/10.3779/j.issn.1009-3419.2012.06.04 Text en 版权所有©《中国肺癌杂志》编辑部2012 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/
spellingShingle 临床研究
甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的Meta分析
title 甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的Meta分析
title_full 甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的Meta分析
title_fullStr 甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的Meta分析
title_full_unstemmed 甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的Meta分析
title_short 甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的Meta分析
title_sort 甘氨双唑钠对非小细胞肺癌放射治疗增敏作用的meta分析
topic 临床研究
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000306/
https://www.ncbi.nlm.nih.gov/pubmed/22681920
http://dx.doi.org/10.3779/j.issn.1009-3419.2012.06.04
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