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AKT2在非小细胞肺癌中的表达及预后意义

BACKGROUND AND OBJECTIVE: AKT2 is a critical actor in the PI3K signal transduction pathway. Activation of AKT2 can lead to cell growth and survival. It has been revealed that AKT2 play a central role in tumorigenesis, tumor growth as well as metastasis. The aim of this study is to investigate the as...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000327/
https://www.ncbi.nlm.nih.gov/pubmed/21569643
http://dx.doi.org/10.3779/j.issn.1009-3419.2011.05.03
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collection PubMed
description BACKGROUND AND OBJECTIVE: AKT2 is a critical actor in the PI3K signal transduction pathway. Activation of AKT2 can lead to cell growth and survival. It has been revealed that AKT2 play a central role in tumorigenesis, tumor growth as well as metastasis. The aim of this study is to investigate the association between AKT2 and the clinical outcome of non-small cell lung cancer (NSCLC) patients by detecting its expression levels in the tumor tissue samples. METHODS: We developed an immunohistochemistry (IHC) assay to measure AKT2 protein levels in lung specimens from 80 cases with NSCLC and 10 cases with benign pulmonary disease. RESULTS: The positive rate of AKT2 was 57.50% (46/80) in NSCLC, which was higher than that in benign pulmonary (10.0%) samples (χ(2)=8.038, P=0.006). There was no significant correlation between AKT2 expression and the clinicopathologic profiles. The expression of AKT2 was significantly correlated with the progression free survival (PFS) (χ(2)=12.671, P=0.005) and the overall survival (OS) (χ(2)=9.851, P=0.021) of patients with NSCLC. CONCLUSION: AKT2 may provide a prognostic bio-marker of NSCLC.
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spelling pubmed-60003272018-07-06 AKT2在非小细胞肺癌中的表达及预后意义 Zhongguo Fei Ai Za Zhi 临床研究 BACKGROUND AND OBJECTIVE: AKT2 is a critical actor in the PI3K signal transduction pathway. Activation of AKT2 can lead to cell growth and survival. It has been revealed that AKT2 play a central role in tumorigenesis, tumor growth as well as metastasis. The aim of this study is to investigate the association between AKT2 and the clinical outcome of non-small cell lung cancer (NSCLC) patients by detecting its expression levels in the tumor tissue samples. METHODS: We developed an immunohistochemistry (IHC) assay to measure AKT2 protein levels in lung specimens from 80 cases with NSCLC and 10 cases with benign pulmonary disease. RESULTS: The positive rate of AKT2 was 57.50% (46/80) in NSCLC, which was higher than that in benign pulmonary (10.0%) samples (χ(2)=8.038, P=0.006). There was no significant correlation between AKT2 expression and the clinicopathologic profiles. The expression of AKT2 was significantly correlated with the progression free survival (PFS) (χ(2)=12.671, P=0.005) and the overall survival (OS) (χ(2)=9.851, P=0.021) of patients with NSCLC. CONCLUSION: AKT2 may provide a prognostic bio-marker of NSCLC. 中国肺癌杂志编辑部 2011-05-20 /pmc/articles/PMC6000327/ /pubmed/21569643 http://dx.doi.org/10.3779/j.issn.1009-3419.2011.05.03 Text en 版权所有©《中国肺癌杂志》编辑部2011 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/
spellingShingle 临床研究
AKT2在非小细胞肺癌中的表达及预后意义
title AKT2在非小细胞肺癌中的表达及预后意义
title_full AKT2在非小细胞肺癌中的表达及预后意义
title_fullStr AKT2在非小细胞肺癌中的表达及预后意义
title_full_unstemmed AKT2在非小细胞肺癌中的表达及预后意义
title_short AKT2在非小细胞肺癌中的表达及预后意义
title_sort akt2在非小细胞肺癌中的表达及预后意义
topic 临床研究
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000327/
https://www.ncbi.nlm.nih.gov/pubmed/21569643
http://dx.doi.org/10.3779/j.issn.1009-3419.2011.05.03
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