PI3K/AKT通路在非小细胞肺癌顺铂耐药中的作用

Accumulating evidences indicate that aberrant activation of PI3K/AKT pathway in non-small cell lung cancer plays a vital role in tumor cell proliferation, apoptosis, and survival including drug resistance.Cisplatin as first-line chemotherapy are in widespread clinical use in patients with non-small cell lung cancer, however, the development of cisplatin resistance significantly impedes its clinic efficacy.Cisplatin resistance is a complicated process that various mechanisms participating in to interact, of which PI3K/AKT pathway keeping sustained activated is one of the most important reasons.This article reviewed the progress of research on the relationship between PI3K/AKT pathway and cisplatin resistance.