Cargando…
奥沙利铂或顺铂联合足叶乙甙治疗老年广泛期小细胞肺癌的随机对照临床研究
BACKGROUND AND OBJECTIVE: Etoposide combined cisplatin (EP) is the most commonly-used first-line treatment combination chemotherapy regimen in the treatment of extensive-stage small cell lung cancer (SCLC), The side-effects of cisplatin, such as nausea and vomiting, influence patients' quality...
Formato: | Online Artículo Texto |
---|---|
Lenguaje: | English |
Publicado: |
中国肺癌杂志编辑部
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000454/ https://www.ncbi.nlm.nih.gov/pubmed/23327869 http://dx.doi.org/10.3779/j.issn.1009-3419.2013.01.04 |
_version_ | 1783331731379585024 |
---|---|
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Etoposide combined cisplatin (EP) is the most commonly-used first-line treatment combination chemotherapy regimen in the treatment of extensive-stage small cell lung cancer (SCLC), The side-effects of cisplatin, such as nausea and vomiting, influence patients' quality of life. This study aims to compare the efficacy and toxicities between etoposide plus oxaliplatin (EO) and etoposide plus cisplatin (EP) regimens as first-line chemotherapy for elderly patients with SCLC. METHODS: Seventy-one old, extensive-stage SCLC patients, who had not received anti-tumor treatment, were randomly divided into two groups, namely, EO group (etoposide: 80 mg/m(2) d1-5+oxaliplatin; 130 mg/m(2) d1; repeated every 21 days) and EP group (etoposide: 80 mg/m(2) d1-5+cisplatin; 25 mg/m(2) d1-3; repeated every 21 days). Efficacy and toxicities were evaluated after 2 or more cycles. RESULTS: No statistical differences were observed between the EO and EP groups in the response rate (55.9% vs 54.3%, P=0.894), disease control rate (82.4% vs 77.1%, P=0.591), median progression free survival (5.5 months vs 4.7 months, P=0.638), and median survival time (10.5 months vs 9.1 months, P=0.862). In terms of toxicities, the incidence of nausea/vomiting in the EO group was significantly lower than that in the EP group (65.7% vs 97.2%, P=0.001), but the neurotoxicity of grade 1-2 in the EO group was more significant (74.3% vs 11.1%, P < 0.001). CONCLUSION: The clinical efficiency of EO and EP regimens is similar to the first-line chemotherapy for extensive-stage SCLC in elderly patients. However, the tolerance of EO regimens is better than that in the EP regiments. |
format | Online Article Text |
id | pubmed-6000454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | 中国肺癌杂志编辑部 |
record_format | MEDLINE/PubMed |
spelling | pubmed-60004542018-07-06 奥沙利铂或顺铂联合足叶乙甙治疗老年广泛期小细胞肺癌的随机对照临床研究 Zhongguo Fei Ai Za Zhi 临床研究 BACKGROUND AND OBJECTIVE: Etoposide combined cisplatin (EP) is the most commonly-used first-line treatment combination chemotherapy regimen in the treatment of extensive-stage small cell lung cancer (SCLC), The side-effects of cisplatin, such as nausea and vomiting, influence patients' quality of life. This study aims to compare the efficacy and toxicities between etoposide plus oxaliplatin (EO) and etoposide plus cisplatin (EP) regimens as first-line chemotherapy for elderly patients with SCLC. METHODS: Seventy-one old, extensive-stage SCLC patients, who had not received anti-tumor treatment, were randomly divided into two groups, namely, EO group (etoposide: 80 mg/m(2) d1-5+oxaliplatin; 130 mg/m(2) d1; repeated every 21 days) and EP group (etoposide: 80 mg/m(2) d1-5+cisplatin; 25 mg/m(2) d1-3; repeated every 21 days). Efficacy and toxicities were evaluated after 2 or more cycles. RESULTS: No statistical differences were observed between the EO and EP groups in the response rate (55.9% vs 54.3%, P=0.894), disease control rate (82.4% vs 77.1%, P=0.591), median progression free survival (5.5 months vs 4.7 months, P=0.638), and median survival time (10.5 months vs 9.1 months, P=0.862). In terms of toxicities, the incidence of nausea/vomiting in the EO group was significantly lower than that in the EP group (65.7% vs 97.2%, P=0.001), but the neurotoxicity of grade 1-2 in the EO group was more significant (74.3% vs 11.1%, P < 0.001). CONCLUSION: The clinical efficiency of EO and EP regimens is similar to the first-line chemotherapy for extensive-stage SCLC in elderly patients. However, the tolerance of EO regimens is better than that in the EP regiments. 中国肺癌杂志编辑部 2013-01-20 /pmc/articles/PMC6000454/ /pubmed/23327869 http://dx.doi.org/10.3779/j.issn.1009-3419.2013.01.04 Text en 版权所有©《中国肺癌杂志》编辑部2013 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | 临床研究 奥沙利铂或顺铂联合足叶乙甙治疗老年广泛期小细胞肺癌的随机对照临床研究 |
title | 奥沙利铂或顺铂联合足叶乙甙治疗老年广泛期小细胞肺癌的随机对照临床研究 |
title_full | 奥沙利铂或顺铂联合足叶乙甙治疗老年广泛期小细胞肺癌的随机对照临床研究 |
title_fullStr | 奥沙利铂或顺铂联合足叶乙甙治疗老年广泛期小细胞肺癌的随机对照临床研究 |
title_full_unstemmed | 奥沙利铂或顺铂联合足叶乙甙治疗老年广泛期小细胞肺癌的随机对照临床研究 |
title_short | 奥沙利铂或顺铂联合足叶乙甙治疗老年广泛期小细胞肺癌的随机对照临床研究 |
title_sort | 奥沙利铂或顺铂联合足叶乙甙治疗老年广泛期小细胞肺癌的随机对照临床研究 |
topic | 临床研究 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000454/ https://www.ncbi.nlm.nih.gov/pubmed/23327869 http://dx.doi.org/10.3779/j.issn.1009-3419.2013.01.04 |
work_keys_str_mv | AT àoshālìbóhuòshùnbóliánhézúyèyǐdàizhìliáolǎoniánguǎngfànqīxiǎoxìbāofèiáidesuíjīduìzhàolínchuángyánjiū AT àoshālìbóhuòshùnbóliánhézúyèyǐdàizhìliáolǎoniánguǎngfànqīxiǎoxìbāofèiáidesuíjīduìzhàolínchuángyánjiū AT àoshālìbóhuòshùnbóliánhézúyèyǐdàizhìliáolǎoniánguǎngfànqīxiǎoxìbāofèiáidesuíjīduìzhàolínchuángyánjiū AT àoshālìbóhuòshùnbóliánhézúyèyǐdàizhìliáolǎoniánguǎngfànqīxiǎoxìbāofèiáidesuíjīduìzhàolínchuángyánjiū |