非小细胞肺癌中EMT的发生机制及预后价值的研究进展

Epithelial to mesenchymal transition (EMT) has an important role in the development of embryo, as well as that in the metastasis of non-small cell lung cancer (NSCLC). Recent researches have demonstrated that both morphological and phenotypic conversions emerge in cells undergoing EMT. As most of re...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2014
Materias:
综述
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000464/
https://www.ncbi.nlm.nih.gov/pubmed/25034589
http://dx.doi.org/10.3779/j.issn.1009-3419.2014.07.13
Descripción
Sumario:Epithelial to mesenchymal transition (EMT) has an important role in the development of embryo, as well as that in the metastasis of non-small cell lung cancer (NSCLC). Recent researches have demonstrated that both morphological and phenotypic conversions emerge in cells undergoing EMT. As most of relevant studies were on other cancers, it is essential to uncover whether it is the similar mechanisms accounting for EMT in NSCLC. With the progress of the studies, EMT-related basic researches are gradually applied to predicting the prognosis of NSCLC. The aim of this article was to discuss the mechanisms related to EMT emerging in NSCLC.

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