Cargando…
艾迪联合紫杉醇和顺铂治疗晚期非小细胞肺癌的meta分析
BACKGROUND AND OBJECTIVE: Compared with chemotherapy, whether aidi injection can improve the patient's quality of life is not definite. The aim of this study is to evaluate the efficacy and safety of axotere plus eisplatin chemotherapy combining aidi injection for patients with non-small cell l...
Formato: | Online Artículo Texto |
---|---|
Lenguaje: | English |
Publicado: |
中国肺癌杂志编辑部
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000489/ https://www.ncbi.nlm.nih.gov/pubmed/21081042 http://dx.doi.org/10.3779/j.issn.1009-3419.2010.11.06 |
_version_ | 1783331743620661248 |
---|---|
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Compared with chemotherapy, whether aidi injection can improve the patient's quality of life is not definite. The aim of this study is to evaluate the efficacy and safety of axotere plus eisplatin chemotherapy combining aidi injection for patients with non-small cell lung cancer (NSCLC). METHODS: We searched relevant randomized controlled trials (RCTs) from Cochrane library, Pubmed, EMBASE, CancerLit, VIP, CBM and CNKI etc. The search was finished in March 20, 2010. We traced the related references and experts in this field, besides we also communicated with other authors to obtain some certain information that has not been found. RCTs of aidi injection plus TP versus TP for advanced NSCLC were included. We evaluated the quality of these included studies and analyzed data by Cochrane Collaboration's RevMan 5.0 software. RESULTS: Eleven RCTs involving 800 patients were included. meta analysis results suggested that compared with TP chemotherapy alone, the combination had a statistically significant benefit in healing efficacy (RR=1.2, 95%CI: 1.10-1.47, P=0.001) and improving quality of life (QOL) (RR=1.85, 95%Cl: 1.54-2.21, P < 0.001). Besides, the combination also had a statistically significant benefit in myelosuppression, white blood cell (WBC)(RR=0.71, 95%CI: 0.57-0.87, P=0.001) and hematoblast (RR=0.59, 95%CI: 0.40-0.87, P=0.008) and in reducing the gastroenteric reaction (RR=0.75, 95%CI: 0.58-0.98, P=0.03). But the combination had no statistically significant benefit in prevention of reducing hemoglobin (Hb) (RR=0.97, 95%CI: 0.70-1.34, P=0.85), liver function (RR=0.63, 95%CI: 0.09-1.57, P=0.18), kidney function (RR=0.42, 95%CI: 0.14-1.24, P=0.12), peripheral neuritis (RR=0.86, 95%CI: 0.56-1.32, P=0.50), and baldness (RR=0.92, 95%CI: 0.63-1.34, P=0.66). CONCLUSION: Compared with TP chemotherapy alone, the combination can significantly improve the efficiency, QOL and myelosuppression, and reduce adverse events. |
format | Online Article Text |
id | pubmed-6000489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | 中国肺癌杂志编辑部 |
record_format | MEDLINE/PubMed |
spelling | pubmed-60004892018-07-06 艾迪联合紫杉醇和顺铂治疗晚期非小细胞肺癌的meta分析 Zhongguo Fei Ai Za Zhi 临床研究 BACKGROUND AND OBJECTIVE: Compared with chemotherapy, whether aidi injection can improve the patient's quality of life is not definite. The aim of this study is to evaluate the efficacy and safety of axotere plus eisplatin chemotherapy combining aidi injection for patients with non-small cell lung cancer (NSCLC). METHODS: We searched relevant randomized controlled trials (RCTs) from Cochrane library, Pubmed, EMBASE, CancerLit, VIP, CBM and CNKI etc. The search was finished in March 20, 2010. We traced the related references and experts in this field, besides we also communicated with other authors to obtain some certain information that has not been found. RCTs of aidi injection plus TP versus TP for advanced NSCLC were included. We evaluated the quality of these included studies and analyzed data by Cochrane Collaboration's RevMan 5.0 software. RESULTS: Eleven RCTs involving 800 patients were included. meta analysis results suggested that compared with TP chemotherapy alone, the combination had a statistically significant benefit in healing efficacy (RR=1.2, 95%CI: 1.10-1.47, P=0.001) and improving quality of life (QOL) (RR=1.85, 95%Cl: 1.54-2.21, P < 0.001). Besides, the combination also had a statistically significant benefit in myelosuppression, white blood cell (WBC)(RR=0.71, 95%CI: 0.57-0.87, P=0.001) and hematoblast (RR=0.59, 95%CI: 0.40-0.87, P=0.008) and in reducing the gastroenteric reaction (RR=0.75, 95%CI: 0.58-0.98, P=0.03). But the combination had no statistically significant benefit in prevention of reducing hemoglobin (Hb) (RR=0.97, 95%CI: 0.70-1.34, P=0.85), liver function (RR=0.63, 95%CI: 0.09-1.57, P=0.18), kidney function (RR=0.42, 95%CI: 0.14-1.24, P=0.12), peripheral neuritis (RR=0.86, 95%CI: 0.56-1.32, P=0.50), and baldness (RR=0.92, 95%CI: 0.63-1.34, P=0.66). CONCLUSION: Compared with TP chemotherapy alone, the combination can significantly improve the efficiency, QOL and myelosuppression, and reduce adverse events. 中国肺癌杂志编辑部 2010-11-20 /pmc/articles/PMC6000489/ /pubmed/21081042 http://dx.doi.org/10.3779/j.issn.1009-3419.2010.11.06 Text en 版权所有©《中国肺癌杂志》编辑部2010 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | 临床研究 艾迪联合紫杉醇和顺铂治疗晚期非小细胞肺癌的meta分析 |
title | 艾迪联合紫杉醇和顺铂治疗晚期非小细胞肺癌的meta分析 |
title_full | 艾迪联合紫杉醇和顺铂治疗晚期非小细胞肺癌的meta分析 |
title_fullStr | 艾迪联合紫杉醇和顺铂治疗晚期非小细胞肺癌的meta分析 |
title_full_unstemmed | 艾迪联合紫杉醇和顺铂治疗晚期非小细胞肺癌的meta分析 |
title_short | 艾迪联合紫杉醇和顺铂治疗晚期非小细胞肺癌的meta分析 |
title_sort | 艾迪联合紫杉醇和顺铂治疗晚期非小细胞肺癌的meta分析 |
topic | 临床研究 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000489/ https://www.ncbi.nlm.nih.gov/pubmed/21081042 http://dx.doi.org/10.3779/j.issn.1009-3419.2010.11.06 |
work_keys_str_mv | AT àidíliánhézǐshānchúnhéshùnbózhìliáowǎnqīfēixiǎoxìbāofèiáidemetafēnxī AT àidíliánhézǐshānchúnhéshùnbózhìliáowǎnqīfēixiǎoxìbāofèiáidemetafēnxī AT àidíliánhézǐshānchúnhéshùnbózhìliáowǎnqīfēixiǎoxìbāofèiáidemetafēnxī AT àidíliánhézǐshānchúnhéshùnbózhìliáowǎnqīfēixiǎoxìbāofèiáidemetafēnxī AT àidíliánhézǐshānchúnhéshùnbózhìliáowǎnqīfēixiǎoxìbāofèiáidemetafēnxī AT àidíliánhézǐshānchúnhéshùnbózhìliáowǎnqīfēixiǎoxìbāofèiáidemetafēnxī AT àidíliánhézǐshānchúnhéshùnbózhìliáowǎnqīfēixiǎoxìbāofèiáidemetafēnxī |