322例非小细胞肺癌骨转移临床特点及治疗的回顾性分析

BACKGROUND AND OBJECTIVE: Bone metastases are the most common metastases of the non-small cell lung cancer (NSCLC). It can lead to bone ache and pathology fracture, deteriorate the quality of life. METHODS: We retrospectively investigated the characteristics, diagnosis and prognosis factors of bone metastases in NSCLC. All of the 600 patients are from department of thoracic oncology in recently 5 years. Emission computed tomography (ECT) was used to screen the bone metastases and the diagnosis of bone metastases was confrmed by computed tomography (CT)/magnetic resonance imaging (MRI)/X-ray or pathology. RESULTS: Among the total 322 bone metastases patients, subtype of adenocarcinoma had the most opportunity to occur bone metastases, and we found that vertebrae, pelvis and femora et al were the most frequently involved metastases sites. Patients who had more than 3 high (18)F-FDG uptake sites of ECT, could be confrmed bone metastases by CT/MRI/X-ray than those with 1-2 high (18)F-FDG uptake sites [80.6% (203/252) vs 50.79% (32/63), P < 0.001]. The patients with bone metastases who had non-SRE had longer survival than that of SRE [1-yr survival 44.75% (non-SRE) vs 36.17% (SRE); median survival 14.74 mo (non-SRE) vs 12.25 mo (SRE)]. Multivariables analysis showed the pathology were non-adnocarcinoma, bone metastases less than 3 sites and bone metastases without other organs metastases would have good prognosis. CONCLUSION: Tere were relations between the numbers of abnormal dense sites of ECT and the diagnosis of skeletal metastases, non-adnocarcinoma bone metastases less than 3 sites and bone metastases without other organs metastases were the independent prognosis factors..