SHP2在非小细胞肺癌中的表达及意义

BACKGROUND AND OBJECTIVE: Precious studies proven that aberrant tyrosine phosphorylation has linked with cancer.The aim of this work is to study the expression and significance of SHP2 in non-small cell lung cancer (NSCLC) through tissue microarray technique and immunohistochemical method. METHODS: Eighty NSCLC specimens were constructed into tissue microarray and performed using immunohistochemistry. RESULTS: The total positive rates of SHP2 were 70.7% (56/80) in NSCLC, 72.5% (29/40) in squamous cell carcinoma and 75% (27/40) in adenocarcinoma, which was not significant difference in sex, age, the size of tumor, histology, clinical stages and differentiation (P > 0.05), the positive rates of SHP2 were significantly higher in the cases with lymphnode metastasis than those without (P < 0.05). CONCLUSION: The expression rate of SHP2 is high and closely correlated to lymphnode metastasis in NSCLC, which implies the occurrence and development of lung cancer may be related to SHP2, and SHP2 may be a new marker and therapeutic targets for lung cancer.